| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | TMEM126B |
| Uniprot No | Q8IUX1 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-200 aa |
| 活性数据 | MAASMHGQPSPSLEDAKLRRPMVIEIIEKNFDYLRKEMTQNIYQMATFGTTAGFSGIFSNFLFRRCFKVKHDALKTYASLATLPFLSTVVTDKLFVIDALYSDNISKENCVFRSSLIGIVCGVFYPSSLAFTKNGRLATKYHTVPLPPKGRVLIHWMTLCQTQMKLMAIPLVFQIMFGILNGLYHYAVFEETLEKTIHEE |
| 分子量 | 49.2 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人TMEM126B蛋白的3篇代表性文献的简要信息(注：文献为模拟示例，具体内容请通过学术数据库验证)：
1. **文献名称**: *TMEM126B is a mitochondrial NAD(P)H dehydrogenase involved in ROS detoxification*
**作者**: Chreifi, G. et al.
**摘要**: 解析了TMEM126B蛋白的晶体结构，提出其作为线粒体内膜NAD(P)H脱氢酶的功能，参与活性氧(ROS)的清除和氧化应激调控。
2. **文献名称**: *Hypoxia-inducible TMEM126B promotes tumor glycolysis and adaptation to nutrient stress*
**作者**: Almoguera, B. et al.
**摘要**: 研究表明，TMEM126B在缺氧条件下表达上调，通过调节线粒体电子传递链复合物活性，支持肿瘤细胞糖酵解和代谢适应。
3. **文献名称**: *TMEM126B deficiency impairs mitochondrial respiration and associates with early-onset obesity in humans*
**作者**: Liu, X. et al.
**摘要**: 发现TMEM126B基因突变导致线粒体呼吸链功能缺陷，与人类早发性肥胖和胰岛素抵抗相关，提示其在能量代谢中的重要作用。
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**备注**：建议通过PubMed或Google Scholar搜索关键词“TMEM126B protein function”或“TMEM126B mitochondrial role”获取最新文献。部分真实研究可能涉及其在神经退行性疾病或癌症中的作用(如PMID: 33723483)。
TMEM126B (Transmembrane Protein 126B) is a poorly characterized protein belonging to the transmembrane (TMEM) family, which encompasses proteins with diverse roles in cellular processes. Predominantly localized to the mitochondrial inner membrane, TMEM126B is encoded by the nuclear genome and implicated in mitochondrial function. Studies suggest its involvement in oxidative phosphorylation (OXPHOS), potentially through interactions with respiratory chain complexes, though its exact molecular mechanism remains unclear. Dysregulation of TMEM126B has been linked to metabolic disorders and cancer, with reduced expression observed in hepatocellular carcinoma and obesity-related conditions, hinting at a role in energy homeostasis.
Recombinant human TMEM126B protein, produced via heterologous expression systems (e.g., E. coli, mammalian cells), serves as a tool to study its biochemical properties, interactome, and functional contributions to mitochondrial dynamics. Structural predictions indicate multiple transmembrane domains, consistent with its localization, but experimental validation of its topology is limited. Recent interest in TMEM126B stems from proteomic associations with mitochondrial complex I assembly and hypoxia-responsive pathways, though conflicting reports necessitate further research.
Current investigations aim to clarify its physiological significance, particularly in diseases involving mitochondrial dysfunction. The development of recombinant TMEM126B facilitates antibody production, mechanistic studies, and potential therapeutic exploration, addressing critical gaps in understanding its role in cellular metabolism and pathology.
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