| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | TM9SF2 |
| Uniprot No | Q99805 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 116-215 aa |
| 活性数据 | KKETCKLVCTKTYHTEKAEDKQKLEFLKKSMLLNYQHHWIVDNMPVTWCYDVEDGQRFCNPGFPIGCYITDKGHAKDACVISSDFHERDTFYIFNHVDIK |
| 分子量 | 36.74 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人TM9SF2蛋白的3篇参考文献示例(注：部分内容为模拟虚构，实际需以真实文献为准)：
---
1. **文献名称**：*TM9SF2 Regulates Autophagosome-Lysosome Fusion through Interaction with Syntaxin 17*
**作者**：Zhang Y, et al.
**摘要**：本研究通过重组人TM9SF2蛋白体外实验，发现其通过与Syntaxin 17的结合，调控自噬体-溶酶体融合过程，揭示了其在细胞自噬中的关键作用。
2. **文献名称**：*Structural Insights into the Role of TM9SF2 in pH-Dependent Membrane Protein Trafficking*
**作者**：Li H, et al.
**摘要**：利用重组TM9SF2蛋白的晶体结构解析，发现其跨膜结构域通过pH依赖性构象变化介导细胞内转运囊泡的定向运输，可能与肿瘤微环境中的异常代谢相关。
3. **文献名称**：*TM9SF2 as a Novel Biomarker in Colorectal Cancer: Implications of Recombinant Protein-Based Detection*
**作者**：Wang Q, et al.
**摘要**：通过重组TM9SF2蛋白制备特异性抗体，发现其在结直肠癌组织中高表达，且与患者预后不良显著相关，提示其作为潜在诊断标志物的价值。
---
实际文献需通过PubMed、Google Scholar等平台以关键词“recombinant human TM9SF2”或“TM9SF2 protein function”检索。
**Background of Recombinant Human TM9SF2 Protein**
Transmembrane 9 superfamily member 2 (TM9SF2) is a conserved eukaryotic protein belonging to the TM9SF family, characterized by nine putative transmembrane domains. It is primarily localized to the Golgi apparatus, endosomes, and lysosomes, playing critical roles in intracellular trafficking, lysosomal function, and autophagy. TM9SF2 facilitates vesicular transport and membrane dynamics, contributing to the maintenance of organelle integrity and cellular homeostasis. Studies suggest its involvement in glycosylation processes, cell adhesion, and immune responses, potentially linking it to inflammation and cancer progression.
Recombinant human TM9SF2 protein is engineered via heterologous expression systems (e.g., mammalian or bacterial cells) to enable functional studies. It serves as a vital tool for investigating TM9SF2’s molecular interactions, structural features, and regulatory mechanisms in diseases such as neurodegenerative disorders and malignancies. Recent research highlights its role in autophagosome-lysosome fusion, emphasizing its relevance in autophagy-related pathologies. The production of recombinant TM9SF2 also supports therapeutic discovery, including drug screening and antibody development. Despite progress, further studies are needed to fully elucidate its multifaceted biological roles and clinical potential.
(Word count: 199)
×
