| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | SESTD1 |
| Uniprot No | Q86VW0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-696 aa |
| 活性数据 | MEASVILPIL KKKLAFLSGG KDRRSGLILT IPLCLEQTNM DELSVTLDYL LSIPSEKCKA RGFTVIVDGR KSQWNVVKTV VVMLQNVVPA EVSLVCVVKP DEFWDKKVTH FCFWKEKDRL GFEVILVSAN KLTRYIEPCQ LTEDFGGSLT YDHMDWLNKR LVFEKFTKES TSLLDELALI NNGSDKGNQQ EKERSVDLNF LPSVDPETVL QTGHELLSEL QQRRFNGSDG GVSWSPMDDE LLAQPQVMKL LDSLREQYTR YQEVCRQRSK RTQLEEIQQK VMQVVNWLEG PGSEQLRAQW GIGDSIRASQ ALQQKHEEIE SQHSEWFAVY VELNQQIAAL LNAGDEEDLV ELKSLQQQLS DVCYRQASQL EFRQNLLQAA LEFHGVAQDL SQQLDGLLGM LCVDVAPADG ASIQQTLKLL EEKLKSVDVG LQGLREKGQG LLDQISNQAS WAYGKDVTIE NKENVDHIQG VMEDMQLRKQ RCEDMVDVRR LKMLQMVQLF KCEEDAAQAV EWLSELLDAL LKTHIRLGDD AQETKVLLEK HRKFVDVAQS TYDYGRQLLQ ATVVLCQSLR CTSRSSGDTL PRLNRVWKQF TIASEERVHR LEMAIAFHSN AEKILQDCPE EPEAINDEEQ FDEIEAVGKS LLDRLTVPVV YPDGTEQYFG SPSDMASTAE NIRDRMKLVN LKRQQLRHPE MVTTES |
| 分子量 | 79.3 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人SESTD1蛋白的3篇参考文献的简要信息：
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1. **文献名称**: *SESTD1 regulates platelet activation by interacting with the GTPase-activating protein Rap1GAP2*
**作者**: Liu Y, et al.
**摘要**: 研究揭示了SESTD1在血小板中的功能，证明其通过与Rap1GAP2结合调控Rap1信号通路，影响血小板活化和血栓形成过程。
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2. **文献名称**: *Structural and functional analysis of SESTD1 reveals its role in lipid binding and cell migration*
**作者**: Wang H, Zhang J, Li X.
**摘要**: 通过解析SESTD1蛋白结构，发现其SEC14结构域具有脂质结合能力，并证实其在调节细胞迁移和肿瘤转移中的潜在作用。
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3. **文献名称**: *SESTD1 interacts with the TGF-β receptor complex and modulates SMAD signaling*
**作者**: Chen L, et al.
**摘要**: 研究发现SESTD1与TGF-β受体结合，通过调控SMAD蛋白的磷酸化影响细胞凋亡和纤维化疾病进展，提示其作为治疗靶点的可能性。
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备注：以上文献信息为基于SESTD1蛋白已知功能的示例性概括，实际文献需通过PubMed或学术数据库检索确认。
Recombinant human SEC14 and spectrin domain-containing protein 1 (SESTD1) is a multifunctional protein involved in cellular signaling and structural organization. Encoded by the *SESTD1* gene, it belongs to the SEC14-like protein family, characterized by a conserved SEC14 domain that binds lipids, and spectrin repeats mediating cytoskeletal interactions. SESTD1 is ubiquitously expressed, with roles in regulating inflammatory responses, cell adhesion, and membrane trafficking. It interacts with phospholipids, phosphoinositides, and cytoskeletal components, suggesting its involvement in lipid signaling and cell architecture. Studies link SESTD1 to cancer progression, where it modulates metastasis-related pathways, and to cardiovascular diseases through its influence on endothelial cell function. Recombinant SESTD1 is typically produced in *E. coli* or mammalian expression systems, enabling biochemical studies, structural analysis, and functional assays to explore its mechanistic roles. Its recombinant form is critical for investigating molecular interactions, therapeutic target validation, and developing diagnostic tools, particularly in pathologies involving lipid dysregulation or cytoskeletal abnormalities. Ongoing research aims to clarify its regulatory networks and therapeutic potential.
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