关键信息
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基因名
RGMB
- 应用
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别名
DRAGON; DRG11-responsive axonal guidance and outgrowth of neurite; Repulsive Guidance Molecule B; RGM b; RGM domain family member B; Rgmb; RGMB_HUMAN
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q6NW40
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表达区间
46-413 aa
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氨基酸序列
GDCQQ PAQCRIQKCT TDFVSLTSHL NSAVDGFDSE FCKALRAYAG CTQRTSKACR GNLVYHSAVL GISDLMSQRN CSKDGPTSST NPEVTHDPCN YHSHAGAREH RRGDQNPPSY LFCGLFGDPH LRTFKDNFQT CKVEGAWPLI DNNYLSVQVT NVPVVPGSSA TATNKITIIF KAHHECTDQK VYQAVTDDLP AAFVDGTTSG GDSDAKSLRI VERESGHYVE MHARYIGTTV FVRQVGRYLT LAIRMPEDLA MSYEESQDLQ LCVNGCPLSE RIDDGQGQVS AILGHSLPRT SLVQAWPGYT LETANTQCHE KMPVKDIYFQ SCVFDLLTTG DANFTAAAHS ALEDVEALHP RKERWHIFPS SGN
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分子量
47.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
RGMB, also known as Restin Globular Motif Binding protein, is a member of the repulsive guidance molecule family, which plays a crucial role in various biological processes, particularly in neural development and regeneration. Research on RGMB has gained attention due to its involvement in guiding neuronal trajectories and influencing cellular communication in the nervous system. Its function as a signaling molecule suggests potential implications in neurodegenerative diseases and developmental disorders. Recent studies have also indicated that RGMB may interact with several receptors, impacting pathways related to cell migration and differentiation. Understanding the molecular mechanisms of RGMB through recombinant protein studies provides insights into its role within the extracellular environment, the formation of synapses, and its potential as a therapeutic target. Exploring RGMB's structure and function not only reveals fundamental aspects of neurobiology but also opens avenues for developing novel strategies in regenerative medicine and neuroprotection. Given the critical need for innovative approaches to address neurological challenges, RGMB continues to be a significant focus of research, bridging gaps in knowledge and paving the way for future therapeutic interventions.
