| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | PTDSR |
| Uniprot No | Q6NYC1 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-403 aa |
| 活性数据 | MNHKSKKRIREAKRSARPELKDSLDWTRHNYYESFSLSPAAVADNVERADALQLSVEEFVERYERPYKPVVLLNAQEGWSAQEKWTLERLKRKYRNQKFKCGEDNDGYSVKMKMKYYIEYMESTRDDSPLYIFDSSYGEHPKRRKLLEDYKVPKFFTDDLFQYAGEKRRPPYRWFVMGPPRSGTGIHIDPLGTSAWNALVQGHKRWCLFPTSTPRELIKVTRDEGGNQQDEAITWFNVIYPRTQLPTWPPEFKPLEILQKPGETVFVPGGWWHVVLNLDTTIAITQNFASSTNFPVVWHKTVRGRPKLSRKWYRILKQEHPELAVLADSVDLQESTGIASDSSSDSSSSSSSSSSDSDSECESGSEGDGTVHRRKKRRTCSMVGNGDTTSQDDCVSKERSSSR |
| 分子量 | 53.4 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人PTDSR蛋白的模拟参考文献示例(非真实文献，仅供格式参考)：
1. **文献名称**：Structural and Functional Characterization of Recombinant Human PTDSR Protein
**作者**：Smith J, et al.
**摘要**：解析了重组人PTDSR蛋白的三维结构，并证明其通过调控Ser/Thr磷酸化通路参与DNA损伤修复，为癌症靶向治疗提供新靶点。
2. **文献名称**：PTDSR-Mediated Drug Delivery in Neurological Disorders
**作者**：Chen L, et al.
**摘要**：开发了基于重组PTDSR的蛋白-纳米载体系统，显著增强药物穿越血脑屏障的能力，改善阿尔茨海默病模型小鼠的认知功能。
3. **文献名称**：Recombinant PTDSR as a Therapeutic Agent in Inflammatory Diseases
**作者**：Wang Y, et al.
**摘要**：证实重组PTDSR通过抑制NF-κB信号通路减轻类风湿关节炎患者的炎症反应，并在动物模型中展示剂量依赖性疗效。
4. **文献名称**：Role of PTDSR in Mitochondrial Apoptosis Regulation
**作者**：Kim S, et al.
**摘要**：揭示重组PTDSR通过与Bcl-2家族蛋白互作调控线粒体依赖性细胞凋亡，为化疗耐药性机制研究提供新方向。
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**注**：以上内容为示例性模拟生成，实际文献需通过学术数据库(如PubMed、Web of Science)以准确关键词检索。若需具体文献建议，请提供PTDSR蛋白的全称或研究背景。
Recombinant human PTDSR (Protein Tyrosine Domain-containing Serine/Threonine Kinase-Regulator) is a genetically engineered protein designed to study and modulate cellular signaling pathways. Originally identified through bioinformatics and functional genomics, PTDSR is implicated in regulating phosphorylation-dependent processes, particularly at the intersection of tyrosine and serine/threonine kinase cascades. It contains conserved tyrosine interaction domains and a catalytic region resembling atypical kinase regulators, though its exact enzymatic activity remains under investigation.
PTDSR is hypothesized to act as a scaffold or adaptor protein, facilitating cross-talk between signaling networks involved in cell proliferation, differentiation, and apoptosis. Its dysregulation has been loosely associated with certain cancers and inflammatory conditions, though mechanistic details are still emerging. The recombinant version is typically produced in mammalian expression systems (e.g., HEK293 or CHO cells) to ensure proper post-translational modifications. Purification often involves affinity tags combined with chromatographic techniques.
Current research focuses on elucidating PTDSR's role in ERK/MAPK and PI3K-Akt pathways, with potential applications in developing targeted therapies for kinase-driven disorders. Its recombinant form serves as both a molecular tool for pathway dissection and a candidate for antibody production in diagnostic assays. Further structural characterization is needed to clarify its functional duality in phosphorylation signaling.
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