| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | PSTPIP2 |
| Uniprot No | Q9H939 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 2-334 aa |
| 活性数据 | TRSLFKGNF WSADILSTIG YDNIIQHLNN GRKNCKEFED FLKERAAIEE RYGKDLLNLS RKKPCGQSEI NTLKRALEVF KQQVDNVAQC HIQLAQSLRE EARKMEEFRE KQKLQRKKTE LIMDAIHKQK SLQFKKTMDA KKNYEQKCRD KDEAEQAVSR SANLVNPKQQ EKLFVKLATS KTAVEDSDKA YMLHIGTLDK VREEWQSEHI KACEAFEAQE CERINFFRNA LWLHVNQLSQ QCVTSDEMYE QVRKSLEMCS IQRDIEYFVN QRKTGQIPPA PIMYENFYSS QKNAVPAGKA TGPNLARRGP LPIPKSSPDD PNYSLVDDYS LLYQ |
| 分子量 | 38.8 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人PSTPIP2蛋白的3篇参考文献(基于虚构摘要，供参考)：
1. **文献名称**: "PSTPIP2 regulates macrophage motility and inflammatory response through cytoskeletal remodeling"
**作者**: Li X, et al.
**摘要**: 本研究揭示了重组人PSTPIP2蛋白通过结合WASP/WAVE复合物调控巨噬细胞骨架动态，抑制过度炎症反应，可能成为炎症性疾病的潜在治疗靶点。
2. **文献名称**: "Structural basis of PSTPIP2 interaction with PTP-PEST in modulating cellular dephosphorylation"
**作者**: Zhang Y, et al.
**摘要**: 通过解析重组人PSTPIP2的晶体结构，发现其与酪氨酸磷酸酶PTP-PEST的相互作用位点，揭示了其在调控细胞信号转导和去磷酸化过程中的分子机制。
3. **文献名称**: "PSTPIP2 deficiency exacerbates autoinflammatory responses in a murine arthritis model"
**作者**: Kumar R, et al.
**摘要**: 利用重组蛋白回补实验，证明PSTPIP2缺失导致IL-1β过度激活，加剧小鼠关节炎模型中的关节炎症，提示其负向调控炎症小体功能。
(注：以上文献及摘要基于领域内相关研究方向的典型内容模拟，实际文献需通过PubMed或Google Scholar检索确认。)
PSTPIP2 (Proline-serine-threonine phosphatase-interacting protein 2) is a cytoskeletal regulatory protein belonging to the F-BAR domain-containing protein family. Primarily expressed in macrophages, dendritic cells, and osteoclasts, it plays crucial roles in membrane deformation, cell motility, and immune regulation. The protein interacts with PTP-PEST (a tyrosine phosphatase) through its coiled-coil domain and regulates actin dynamics by modulating WASP/WAVE-family proteins.
Studies link PSTPIP2 to inflammatory responses and autoinflammatory disorders. Mutations in PSTPIP2 are associated with chronic multifocal osteomyelitis in mice, while human homologs may contribute to arthritis and autoinflammatory diseases. Unlike its relative PSTPIP1 (linked to PAPA syndrome), PSTPIP2 appears to function as a negative regulator of inflammation, potentially suppressing NLRP3 inflammasome activation and IL-1β secretion.
Recombinant human PSTPIP2 protein is engineered for research into immune signaling pathways and inflammatory disease mechanisms. Produced via bacterial or mammalian expression systems, it serves as a tool for studying protein-protein interactions, cytoskeletal remodeling, and macrophage biology. Its therapeutic potential in modulating excessive inflammation remains an active area of investigation, particularly in bone-related inflammatory conditions.
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