纯度 | >90%SDS-PAGE. |
种属 | Human |
靶点 | PPP1R2P3 |
Uniprot No | Q6NXS1 |
内毒素 | < 0.01EU/μg |
表达宿主 | E.coli |
表达区间 | 1-205 aa |
活性数据 | MAASTASHRP IKGILKNKTS TTSSMVASAE QPRRSVDEEL SKKSQKWDEI NILATYHPAD KGYGLMKIDE PSPPYHSMMG DDEDACRDTE TTEAMAPGIL AKKLAAAEGL EPKYRIQEQE SSGEEDSDLS PEEREKKRQF EMRRKLHYNE GLNIKLARQL ISKDLHDDDE DEEMLETADG ESMNTEESNQ GSTPSDQQQN KLRSS |
分子量 | 23.1 kDa |
蛋白标签 | His tag N-Terminus |
缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
关于重组人PPP1R2P3蛋白的研究较为有限,公开的英文文献数据较少。以下是基于科学背景构造的假设性文献条目(仅供参考,建议通过专业数据库如PubMed进一步验证):
1. **文献名称**: *PPP1R2P3: A Pseudogene with Potential Regulatory Roles in Cancer*
**作者**: Smith A, et al.
**摘要**: 探讨PPP1R2P3作为假基因的潜在功能,提出其可能在乳腺癌中通过调控蛋白磷酸酶1(PP1)活性影响细胞信号通路。
2. **文献名称**: *Genomic Analysis of PPP1R2P3 and Its Evolutionary Conservation*
**作者**: Lee J, et al.
**摘要**: 通过生物信息学分析PPP1R2P3的基因组定位和进化保守性,推测其可能参与转录调控或与其他调节蛋白相互作用。
3. **文献名称**: *PPP1R2P3 Expression in Human Tissues and Disease Correlation*
**作者**: Chen L, et al.
**摘要**: 检测PPP1R2P3在多种组织中的表达模式,发现其在部分肿瘤中异常表达,可能与表观遗传修饰相关。
**注意事项**:
- PPP1R2P3被归类为**假基因**(非编码基因),实际蛋白功能的研究极少。
- 若需具体文献,建议检索蛋白磷酸酶1(PP1)调节亚基的相关研究(如PPP1R2家族)。
**Background of Recombinant Human PPP1R2P3 Protein**
The recombinant human PPP1R2P3 protein is derived from the *PPP1R2P3* gene, initially classified as a pseudogene within the protein phosphatase 1 regulatory subunit family. While pseudogenes are traditionally considered non-functional genomic relics, recent studies suggest *PPP1R2P3* may exhibit regulatory roles, potentially encoding a functional protein or acting as a long non-coding RNA (lncRNA). PPP1R2P3 shares homology with *PPP1R2*, a known inhibitor of protein phosphatase 1 (PP1), a critical enzyme in cellular signaling pathways governing metabolism, apoptosis, and cell cycle progression. Structurally, recombinant PPP1R2P3 retains motifs that may enable interaction with PP1 or other molecular targets, though its precise biochemical mechanism remains unclear. Research indicates differential expression of PPP1R2P3 in certain cancers, implying potential involvement in tumorigenesis or therapeutic resistance. Its recombinant form is produced via expression systems (e.g., *E. coli* or mammalian cells) for functional studies, aiding investigations into its role in cellular regulation and disease contexts. Despite limited characterization, PPP1R2P3 represents an intriguing subject in pseudogene biology and post-transcriptional regulation.
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