| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | PPAN-P2RY11 |
| Uniprot No | A0A0B4J1V8 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-794 aa |
| 活性数据 | MGQSGRSRHQKRARAQAQLRNLEAYAANPHSFVFTRGCTGRNIRQLSLDVRRVMEPLTASRLQVRKKNSLKDCVAVAGPLGVTHFLILSKTETNVYFKLMRLPGGPTLTFQVKKYSLVRDVVSSLRRHRMHEQQFAHPPLLVLNSFGPHGMHVKLMATMFQNLFPSINVHKVNLNTIKRCLLIDYNPDSQELDFRHYSIKVVPVGASRGMKKLLQEKFPNMSRLQDISELLATGAGLSESEAEPDGDHNITELPQAVAGRGNMRAQQSAVRLTEIGPRMTLQLIKVQEGVGEGKVMFHSFVSKTEEELQAILEAKEKKLRLKAQRQAQQAQNVQRKQEQREAHRKKSLEGMKKARVGGSDEEASGIPSRTASLELGEDDDEQEDDDIEYFCQAVGEAPSEDLFPEAKQKRLAKSPGRKRKRWEMDRGAKSCPANFLAAADDKLSGFQGDFLWPILVVEFLVAVASNGLALYRFSIRKQRPWHPAVVFSVQLAVSDLLCALTLPPLAAYLYPPKHWRYGEAACRLERFLFTCNLLGSVIFITCISLNRYLGIVHPFFARSHLRPKHAWAVSAAGWVLAALLAMPTLSFSHLKRPQQGAGNCSVARPEACIKCLGTADHGLAAYRAYSLVLAGLGCGLPLLLTLAAYGALGRAVLRSPGMTVAEKLRVAALVASGVALYASSYVPYHIMRVLNVDARRRWSTRCPSFADIAQATAALELGPYVGYQVMRGLMPLAFCVHPLLYMAAVPSLGCCCRHCPGYRDSWNPEDAKSTGQALPLNATAAPKPSEPQSRELSQ |
| 分子量 | 87.4 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是假设性的重组人PPAN-P2RY11蛋白研究文献示例(非真实存在，仅作参考)：
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1. **《重组人PPAN-P2RY11融合蛋白的构建及功能表征》**
*作者：Zhang L. et al.*
摘要：本研究成功构建了PPAN-P2RY11的重组融合蛋白，并利用HEK293细胞表达系统进行高效分泌表达。通过亲和层析纯化后，证实该蛋白可激活下游cAMP信号通路，并在体外抑制特定癌细胞的增殖。
2. **《PPAN-P2RY11在免疫调控中的双重作用机制》**
*作者：Smith K. & Müller R.*
摘要：通过重组PPAN-P2RY11蛋白实验发现，其可能通过结合巨噬细胞表面受体调控炎症因子释放，同时促进调节性T细胞分化，为自身免疫疾病治疗提供了潜在靶点。
3. **《基于重组PPAN-P2RY11的癌症治疗靶向药物开发》**
*作者：Chen X. et al.*
摘要：该研究利用重组PPAN-P2RY11蛋白偶联纳米载体，在小鼠模型中显著增强了药物对实体瘤的靶向性，并通过激活肿瘤微环境中的凋亡通路抑制肿瘤生长。
4. **《PPAN结构域对P2RY11受体功能影响的分子机制》**
*作者：Garcia M. et al.*
摘要：通过结构生物学分析揭示，重组PPAN-P2RY11蛋白中PPAN的N端结构域可稳定P2RY11的活性构象，增强其对ATP类似物的结合亲和力，进而调节细胞代谢过程。
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注：以上为模拟生成的参考文献，实际研究中请通过学术数据库(如PubMed、Web of Science)检索真实文献。
Here’s a concise description of recombinant human PPAN-P2RY11 protein:
Recombinant human PPAN-P2RY11 is a genetically engineered fusion protein combining two distinct functional domains: PPAN (Proliferating Cell Nuclear Antigen-associated Protein) and P2RY11 (Purinergic Receptor P2Y11). PPAN, also known as SSP1 or C4orf17. plays a role in ribosomal RNA processing and mitochondrial function, with implications in cell proliferation and apoptosis regulation. P2RY11. a G protein-coupled purinergic receptor, binds extracellular ATP and modulates immune responses, inflammation, and cellular energy metabolism. The recombinant fusion aims to study potential crosstalk between these pathways or create a bifunctional therapeutic agent. Produced typically in mammalian expression systems (e.g., HEK293 or CHO cells), it retains post-translational modifications critical for receptor activity and protein interactions. Research applications include investigating mitochondrial-nuclear signaling, immune-metabolic interfaces, and cancer biology, particularly in tumors where both ribosomal biogenesis and purinergic signaling are dysregulated. Its dual functionality also makes it a candidate tool for targeted drug delivery studies. Current investigations focus on its structural dynamics, ligand-binding properties, and potential therapeutic applications in inflammatory diseases and oncology.
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