| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | PEX11G |
| Uniprot No | Q96HA9 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 0 |
| 活性数据 | MASLSGLASALESYRGRDRLIRVLGYCCQLVGGVLVEQCPARSEVGTRLLVVSTQLSHCRTILRLFDDLAMFVYTKQYGLGAQEEDAFVRCVSVLGNLADQLYYPCEHVAWAADARVLHVDSSRWWTLSTTLWALSLLLGVARSLWMLLKLRQRLRSPTAPFTSPLPRGKRRAMEAQMQSEALSLLSNLADLANAVHWLPRGVLWAGRFPPWLVGLMGTISSILSMYQAARAGGQAEATTP |
| 分子量 | 26.6 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人PEX11G蛋白的3篇参考文献(内容基于典型研究方向虚构，供参考)：
1. **《PEX11G regulates peroxisome proliferation through interaction with DRP1》**
- **作者：Chen L., et al.**
- **摘要**：研究发现PEX11G通过与动力相关蛋白DRP1结合，调控过氧化物酶体的分裂过程，揭示其在细胞器动态平衡中的关键作用。
2. **《Structural insights into human PEX11G and its role in membrane dynamics》**
- **作者：Wang Y., et al.**
- **摘要**：利用X射线晶体学解析了PEX11G的蛋白结构，并验证其C端螺旋结构对过氧化物酶体膜延伸的必要性，为相关代谢疾病机制提供依据。
3. **《PEX11G deficiency disrupts lipid metabolism and promotes hepatocellular carcinoma》**
- **作者：Kim S., et al.**
- **摘要**：在小鼠模型中，PEX11G缺失导致过氧化物酶体功能异常，引发肝脏脂质蓄积并加速肝癌发展，提示其潜在肿瘤抑制功能。
注：以上文献为模拟生成，实际研究中请通过PubMed或Web of Science检索真实发表论文。
**Background of Recombinant Human PEX11G Protein**
The peroxisomal membrane protein PEX11G (Peroxisomal Biogenesis Factor 11 Gamma) is a member of the PEX11 protein family, which plays a critical role in peroxisome proliferation, membrane dynamics, and metabolic functions. Peroxisomes are essential organelles involved in lipid metabolism, reactive oxygen species detoxification, and bile acid synthesis. PEX11G, encoded by the *PEX11G* gene, is one of three mammalian PEX11 isoforms (α, β, γ) and is particularly associated with regulating peroxisome morphology and abundance through membrane remodeling processes.
Recombinant human PEX11G protein is engineered using biotechnological methods, such as expression in bacterial or mammalian systems, to produce purified, functional protein for research applications. Its study is vital for understanding peroxisome-related disorders, including Zellweger spectrum disorders and rhizomelic chondrodysplasia punctata, which are linked to peroxisomal biogenesis defects. Researchers utilize recombinant PEX11G to investigate protein interactions, peroxisome assembly mechanisms, and its role in cellular homeostasis. Structural studies of the protein also aim to elucidate domains responsible for membrane binding and oligomerization, which are crucial for its function. Additionally, recombinant PEX11G serves as a tool for developing therapeutic strategies targeting peroxisomal dysfunctions.
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