| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | PEX11B |
| Uniprot No | O96011 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-259 aa |
| 活性数据 | MDAWVRFSAQSQARERLCRAAQYACSLLGHALQRHGASPELQKQIRQLESHLSLGRKLLRLGNSADALESAKRAVHLSDVVLRFCITVSHLNRALYFACDNVLWAGKSGLAPRVDQEKWAQRSFRYYLFSLIMNLSRDAYEIRLLMEQESSACSRRLKGSGGGVPGGSETGGLGGPGTPGGGLPQLALKLRLQVLLLARVLRGHPPLLLDVVRNACDLFIPLDKLGLWRCGPGIVGLCGLVSSILSILTLIYPWLRLKP |
| 分子量 | 54.8 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下为3篇与重组人PEX11B蛋白相关的参考文献(内容基于公开研究主题归纳，非真实文献)：
1. **文献名称**：*PEX11B promotes peroxisome elongation and interacts with dynamin-like protein 1*
**作者**：Schrader M, et al.
**摘要**：研究证实重组人PEX11B蛋白在过氧化物酶体膜延伸中的作用，发现其通过与动力蛋白DLP1互作介导膜重塑，为过氧化物酶体分裂机制提供新见解。
2. **文献名称**：*Expression and purification of recombinant human PEX11B in E. coli for functional studies*
**作者**：Wang Y, Li X.
**摘要**：描述利用大肠杆菌表达系统高效表达重组人PEX11B蛋白，并通过亲和层析纯化获得高纯度蛋白，验证其诱导过氧化物酶体增殖的活性。
3. **文献名称**：*PEX11B deficiency disrupts peroxisome morphology and exacerbates lipid metabolism disorders*
**作者**：Smith J, et al.
**摘要**：利用重组PEX11B蛋白缺失模型揭示其在脂代谢中的关键作用，突变导致过氧化物酶体碎片化并引发细胞内脂质蓄积。
(注：以上文献为示例性质，实际文献需通过PubMed或学术数据库检索确认。)
The recombinant human PEX11B protein is a critical regulator of peroxisome dynamics, playing a central role in the proliferation, elongation, and division of peroxisomes—membrane-bound organelles essential for lipid metabolism, reactive oxygen species detoxification, and bile acid synthesis. As a member of the PEX11 protein family, PEX11B localizes to peroxisomal membranes and interacts with membrane-shaping proteins (e.g., FIS1. DRP1) to mediate membrane remodeling. Structurally, it contains conserved α-helical domains and hydrophobic regions that facilitate membrane association and protein-protein interactions. Dysregulation of PEX11B is linked to peroxisome biogenesis disorders (PBDs), such as Zellweger spectrum disorders, characterized by neurological impairment and metabolic dysfunction. Recombinant PEX11B, typically produced in E. coli or mammalian expression systems, enables mechanistic studies of peroxisomal dynamics and disease modeling. Its applications extend to exploring therapeutic strategies for PBDs, metabolic syndromes, and neurodegenerative diseases linked to peroxisomal defects. Recent studies also suggest roles in cellular adaptation to metabolic stress, cancer progression, and viral infections, highlighting its broader biomedical relevance.
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