| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | PDZRN3 |
| Uniprot No | Q9UPQ7 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-1066 aa |
| 活性数据 | MGFELDRFDGDVDPDLKCALCHKVLEDPLTTPCGHVFCAGCVLPWVVQEGSCPARCRGRLSAKELNHVLPLKRLILKLDIKCAYATRGCGRVVKLQQLPEHLERCDFAPARCRHAGCGQVLLRRDVEAHMRDACDARPVGRCQEGCGLPLTHGEQRAGGHCCARALRAHNGALQARLGALHKALKKEALRAGKREKSLVAQLAAAQLELQMTALRYQKKFTEYSARLDSLSRCVAAPPGGKGEETKSLTLVLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNGRDLSRATHDQAVEAFKTAKEPIVVQVLRRTPRTKMFTPPSESQLVDTGTQTDITFEHIMALTKMSSPSPPVLDPYLLPEEHPSAHEYYDPNDYIGDIHQEMDREELELEEVDLYRMNSQDKLGLTVCYRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRIIQINGIEVQNREEAVALLTSEENKNFSLLIARPELQLDEGWMDDDRNDFLDDLHMDMLEEQHHQAMQFTASVLQQKKHDEDGGTTDTATILSNQHEKDSGVGRTDESTRNDESSEQENNGDDATASSNPLAGQRKLTCSQDTLGSGDLPFSNESFISADCTDADYLGIPVDECERFRELLELKCQVKSATPYGLYYPSGPLDAGKSDPESVDKELELLNEELRSIELECLSIVRAHKMQQLKEQYRESWMLHNSGFRNYNTSIDVRRHELSDITELPEKSDKDSSSAYNTGESCRSTPLTLEISPDNSLRRAAEGISCPSSEGAVGTTEAYGPASKNLLSITEDPEVGTPTYSPSLKELDPNQPLESKERRASDGSRSPTPSQKLGSAYLPSYHHSPYKHAHIPAHAQHYQSYMQLIQQKSAVEYAQSQMSLVSMCKDLSSPTPSEPRMEWKVKIRSDGTRYITKRPVRDRLLRERALKIREERSGMTTDDDAVSEMKMGRYWSKEERKQHLVKAKEQRRRREFMMQSRLDCLKEQQAADDRKEMNILELSHKKMMKKRNKKIFDNWMTIQELLTHGTKSPDGTRVYNSFLSVTTV |
| 分子量 | 146 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是3篇关于PDZRN3蛋白的参考文献示例(注：文献信息为示例性质，具体内容请以实际论文为准)：
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1. **标题**：*PDZRN3 regulates skeletal muscle regeneration via ubiquitination-mediated degradation of MyoD*
**作者**：H. Tanaka et al.
**摘要**：研究揭示了PDZRN3作为E3泛素连接酶，通过靶向泛素化降解转录因子MyoD，负向调控骨骼肌细胞分化及损伤修复过程，提示其在肌肉再生中的关键作用。
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2. **标题**：*PDZRN3 interacts with Plexin-A receptors to modulate axonal guidance in neurons*
**作者**：M. Yamamoto et al.
**摘要**：本研究证明PDZRN3通过PDZ结构域与Plexin-A受体家族结合，参与Semaphorin信号通路，调控神经元轴突导向和突触可塑性，为神经发育障碍提供潜在机制解释。
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3. **标题**：*The role of PDZRN3 in promoting breast cancer metastasis through Wnt/β-catenin activation*
**作者**：L. Chen et al.
**摘要**：实验表明，PDZRN3在乳腺癌中高表达，通过稳定β-catenin蛋白激活Wnt信号通路，增强肿瘤细胞侵袭能力，提示其作为癌症治疗靶点的可能性。
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(注：如需具体文献，建议通过PubMed、Google Scholar等平台以“PDZRN3”为关键词检索近年研究。)
PDZRN3 (PDZ Domain Containing RING Finger 3), also known as LNX3. is a member of the ligand of Numb protein-X (LNX) family characterized by its modular structure. It contains an N-terminal PDZ domain, which mediates protein-protein interactions by binding to specific C-terminal motifs, and a C-terminal RING finger domain conferring E3 ubiquitin ligase activity. This dual-domain architecture enables PDZRN3 to regulate ubiquitination-dependent processes, such as protein localization, degradation, and signal transduction.
Primarily studied in developmental and cellular contexts, PDZRN3 is implicated in muscle differentiation, synapse formation, and neuronal development. It interacts with cytoskeletal components and signaling molecules, including Numb and MICAL1. influencing cell polarity and morphogenesis. Dysregulation of PDZRN3 has been linked to cancer progression, where it may act as an oncogene or tumor suppressor depending on tissue context. For instance, it promotes degradation of pro-differentiation factors in certain cancers, yet suppresses Wnt/β-catenin signaling in others.
Recombinant PDZRN3 protein, produced via bacterial or mammalian expression systems, is widely used to study its biochemical properties, domain-specific interactions, and functional mechanisms in vitro. Its role in ubiquitination pathways and disease associations makes it a potential therapeutic target, driving interest in structural and functional analyses using recombinant constructs. Ongoing research aims to elucidate its context-dependent roles in health and disease.
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