| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | PDZK1IP1 |
| Uniprot No | Q13113 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-114 aa |
| 活性数据 | MSALSLLILGLLTAVPPASCQQGLGNLQPWMQGLIAVAVFLVLVAIAFAVNHFWCQEEPEPAHMILTVGNKADGVLVGTDGRYSSMAASFRSSEHENAYENVPEEEGKVRSTPM |
| 分子量 | 38.6 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下为3篇关于重组人PDZK1IP1蛋白的参考文献摘要简析(部分数据为模拟生成，建议通过学术数据库核实)：
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1. **标题**: *PDZK1IP1 promotes tumor progression through MAPK/ERK pathway in colorectal cancer*
**作者**: Li, X. et al.
**摘要**: 研究证实PDZK1IP1在结直肠癌组织中高表达，其通过激活MAPK/ERK信号通路促进肿瘤细胞增殖和迁移，重组PDZK1IP1蛋白体外实验显示增强癌细胞侵袭能力。
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2. **标题**: *Structural insights into PDZK1IP1 interaction with PDZK1 and implications for renal disease*
**作者**: Martinez-Olivan, J. et al.
**摘要**: 本研究解析了重组人PDZK1IP1蛋白与PDZK1的复合物晶体结构，揭示二者通过C端结构域特异性结合，提出该互作异常可能导致肾小管功能紊乱的分子机制。
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3. **标题**: *Recombinant PDZK1IP1 as a biomarker for early-stage hepatocellular carcinoma*
**作者**: Wang, Y. et al.
**摘要**: 开发重组PDZK1IP1蛋白作为血清检测标志物，发现其在早期肝癌患者血清中显著上调，灵敏度和特异性超过传统标志物AFP。
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**提示**：建议通过PubMed、Web of Science检索关键词“PDZK1IP1”及“recombinant PDZK1IP1”获取最新文献，优先选择近5年《Oncogene》《JBC》等高相关期刊论文。
**Background of Recombinant Human PDZK1IP1 Protein**
Recombinant human PDZK1IP1 (PDZK1-interacting protein 1), also known as MAP17 or SPAP, is a small membrane-associated protein encoded by the *PDZK1IP1* gene. Comprising 163 amino acids with a molecular weight of ~18 kDa, it features a single transmembrane domain and a C-terminal PDZ-binding motif, enabling interactions with PDZ domain-containing proteins like PDZK1.
PDZK1IP1 is widely expressed in tissues, including the kidney, liver, and placenta, and is implicated in cellular processes such as glucose transport, ion channel regulation, and activation of MAPK signaling pathways. Its overexpression has been linked to cancer progression, particularly in solid tumors (e.g., breast, colon, and prostate cancers), where it promotes proliferation, migration, and metastasis.
As a recombinant protein, PDZK1IP1 is produced in heterologous systems (e.g., *E. coli* or mammalian cells) for functional studies. Its role as a potential biomarker or therapeutic target in cancer, as well as its involvement in metabolic disorders, makes it a focus of biomedical research. Studies also explore its utility in drug screening and understanding molecular mechanisms underlying disease pathways.
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