| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | PCDH11Y |
| Uniprot No | Q9BZA8 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 57-165 aa |
| 活性数据 | EKNYTIREEIPENVLIGNLLKDLNLSLIPNKSLTTTMQFKLVYKTGDVPLIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDIN |
| 分子量 | 37.73 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人PCDH11Y蛋白的假设性参考文献示例(基于已知研究方向和推测内容，建议通过学术数据库进一步核实)：
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1. **文献名称**：*Protocadherin 11Y regulates neuronal migration and cortical development through Rho GTPase signaling*
**作者**：C. Smith et al.
**摘要**：本研究利用重组PCDH11Y蛋白发现其在神经元迁移中的关键作用，通过激活RhoA信号通路调控皮质层形成，揭示了其在人类大脑进化中的潜在意义。
2. **文献名称**：*Recombinant PCDH11Y expression in HEK293 cells reveals homophilic adhesion properties*
**作者**：L. García et al.
**摘要**：通过HEK293系统成功表达重组PCDH11Y蛋白，证实其同源亲和性结合特性，并解析了其细胞外结构域的关键结合位点。
3. **文献名称**：*PCDH11Y gene variants alter protein function and associate with autism spectrum disorder in males*
**作者**：K. Tanaka et al.
**摘要**：发现PCDH11Y基因变异导致重组蛋白功能异常，可能与男性自闭症患者突触发育障碍相关，提示其神经发育中的性别二态性作用。
4. **文献名称**：*Structural characterization of PCDH11Y extracellular domain by X-ray crystallography*
**作者**：M. Evans & R. Patel
**摘要**：首次解析重组PCDH11Y蛋白胞外域的晶体结构，揭示其独特的钙离子结合模体，为研究原钙粘蛋白家族进化提供结构基础。
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**注意**：以上文献为假设性示例，如需真实文献，建议使用关键词“PCDH11Y recombinant protein”在**PubMed**、**Google Scholar**或**Web of Science**中检索最新研究。已知真实研究中，PCDH11Y常被讨论与大脑偏侧化、语言进化及精神疾病相关。
**Background of Protocadherin 11 Y-linked (PCDH11Y) Protein**
Protocadherin 11 Y-linked (PCDH11Y) is a cell adhesion protein encoded by the *PCDH11Y* gene located on the Y chromosome. It belongs to the protocadherin family, a subgroup of cadherin superfamily proteins involved in cell-cell adhesion, neuronal development, and synaptic connectivity. PCDH11Y shares homology with its X-linked counterpart, *PCDH11X*, but differs in evolutionary history and expression patterns due to its Y-chromosome specificity.
Structurally, PCDH11Y contains extracellular cadherin repeats, a transmembrane domain, and a cytoplasmic tail, mediating calcium-dependent homophilic interactions. It plays roles in neuronal migration, axon guidance, and brain asymmetry, with implications in human-specific brain evolution. Studies suggest its involvement in neurodevelopmental disorders, such as autism and schizophrenia, and associations with male-biased conditions.
Research on recombinant PCDH11Y focuses on its structural and functional characterization, often produced via heterologous expression systems (e.g., mammalian or bacterial cells). This enables investigations into its binding mechanisms, signaling pathways, and potential therapeutic applications, including targeting neurological disorders or cancers linked to cadherin dysregulation. However, its exact molecular roles and interactions remain partially unresolved, necessitating further studies to clarify its contributions to health and disease.
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