| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | PCDH11X |
| Uniprot No | Q9BZA7 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 57-165 aa |
| 活性数据 | EKNYTIREEIPENVLIGNLLKDLNLSLIPNKSLTTTMQFKLVYKTGDVPLIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDIN |
| 分子量 | 37.73 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人PCDH11X蛋白的参考文献，基于现有知识库信息整理：
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1. **标题**：*"Protocadherin 11X regulates neuronal migration and cortical lamination in the developing cerebral cortex"*
**作者**：Smith A, et al.
**摘要**：该研究通过重组人PCDH11X蛋白体外功能实验，发现其在神经元迁移和皮层分层中起关键作用，揭示了其通过Wnt信号通路调控细胞黏附的分子机制。
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2. **标题**：*"Structural insights into the dimerization of PCDH11X and its role in X-linked intellectual disability"*
**作者**：Chen B, et al.
**摘要**：利用重组PCDH11X胞外域蛋白进行晶体结构解析，阐明了其同源二聚化界面，并发现特定突变导致X染色体连锁智力障碍的潜在致病机制。
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3. **标题**：*"Recombinant PCDH11X enhances breast cancer cell invasion via EGFR signaling activation"*
**作者**：Kim D, et al.
**摘要**：研究发现重组表达的PCDH11X蛋白通过结合表皮生长因子受体(EGFR)并激活下游MAPK通路，促进乳腺癌细胞的侵袭转移能力。
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**备注**：以上参考文献为模拟示例，实际文献需通过PubMed或Google Scholar等平台以关键词“recombinant PCDH11X”检索获取。建议结合具体研究方向(如神经疾病、癌症等)筛选高相关度文献。
Protocadherin 11 X-linked (PCDH11X) is a member of the protocadherin superfamily, a subgroup of calcium-dependent cell adhesion molecules critical for neural development, synaptic specificity, and intercellular signaling. Located on the X chromosome (Xq21.3), PCDH11X is unique to humans and great apes, with its evolutionary emergence linked to the divergence of hominids. It encodes a single-pass transmembrane protein containing seven extracellular cadherin repeats, a transmembrane domain, and a cytoplasmic tail with conserved motifs for intracellular signaling.
PCDH11X is implicated in cerebral cortical development, particularly in lateralization and hominid-specific brain expansion. Studies suggest roles in neuronal migration, axon guidance, and synapse formation, potentially contributing to human-specific cognitive traits. Its recombination with the Y-linked homolog (PCDH11Y) during evolution may have influenced asymmetrical brain functions, such as language processing.
Dysregulation of PCDH11X has been associated with neuropsychiatric disorders (e.g., schizophrenia, autism spectrum disorder), neurodegenerative conditions, and cancer. As a recombinant protein, PCDH11X is typically expressed in mammalian systems to study its adhesion properties, signaling pathways, and interactions with cytoskeletal components. Current research focuses on elucidating its role in neural circuit assembly, disease mechanisms, and potential therapeutic targeting. However, functional redundancy with other protocadherins and sex-specific effects due to its X-linked nature remain areas of active investigation.
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