关键信息
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基因名
PRRX1
- 应用
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别名
AGOTC; Homeobox protein PHOX1; Paired mesoderm homeo box 1; Paired mesoderm homeobox 1; paired mesoderm homeobox 1 isoform pmx-1b; Paired mesoderm homeobox protein 1; Paired related homeobox 1; Paired related homeobox protein 1; Paired-related homeobox protein 1; PHOX 1; PHOX1 1. 2; PHOX1; PMX 1; PMX1; PRRX 1; Prrx1; PRRX1_HUMAN; PRX 1 ; PRX-1; PRX1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P54821
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表达区间
1-245 aa
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氨基酸序列
MTSSYGHVLE RQPALGGRLD SPGNLDTLQA KKNFSVSHLL DLEEAGDMVA AQADENVGEA GRSLLESPGL TSGSDTPQQD NDQLNSEEKK KRKQRRNRTT FNSSQLQALE RVFERTHYPD AFVREDLARR VNLTEARVQV WFQNRRAKFR RNERAMLANK NASLLKSYSG DVTAVEQPIV PRPAPRPTDY LSWGTASPYS AMATYSATCA NNSPAQGINM ANSIANLRLK AKEYSLQRNQ VPTVN
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分子量
27.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
PRRX1, or Paired Related Homeobox 1, is a member of the homeobox gene family, which plays a pivotal role in various developmental processes and has been implicated in multiple cellular functions, including migration, differentiation, and proliferation. Recent studies have highlighted its potential involvement in cancer progression, particularly in facilitating epithelial-mesenchymal transition (EMT), a critical event that enhances metastasis in solid tumors. The dual roles of PRRX1 as both a tumor suppressor and promoter, depending on the cancer context, underscore its complexity and importance in tumor biology. Research has demonstrated that PRRX1 can regulate key signaling pathways, including the transforming growth factor-beta (TGF-β) pathway, further linking it to cancer metastasis and stemness characteristics in tumors. Given its influential roles, characterizing PRRX1 through recombinant protein studies can provide insights into its functional mechanisms and interactions with other molecular players in cancer and developmental biology. Understanding PRRX1’s structure and function may also pave the way for novel therapeutic strategies targeting cancer metastasis and improving outcomes in patients with aggressive malignancies. The generation of PRRX1 recombinant proteins enables detailed exploration of its biochemical properties, interactions, and regulatory networks, making it a focal point for ongoing research in the fields of molecular biology and oncology.
