| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | MPZL2 |
| Uniprot No | O60487 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-215 aa |
| 活性数据 | MYGKSSTRAVLLLLGIQLTALWPIAAVEIYTSRVLEAVNGTDARLKCTFSSFAPVGDALTVTWNFRPLDGGPEQFVFYYHIDPFQPMSGRFKDRVSWDGNPERYDASILLWKLQFDDNGTYTCQVKNPPDVDGVIGEIRLSVVHTVRFSEIHFLALAIGSACALMIIIVIVVVLFQHYRKKRWAERAHKVVEIKSKEEERLNQEKKVSVYLEDTD |
| 分子量 | 50.9 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人MPZL2蛋白的3篇参考文献示例(注：文献为虚构示例，实际研究需通过学术数据库验证)：
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1. **文献名称**：*MPZL2 Promotes Breast Cancer Metastasis via EGFR Signaling Pathway*
**作者**：Zhang, Y. et al. (2020)
**摘要**：该研究通过CRISPR-Cas9筛选发现MPZL2在乳腺癌细胞中高表达，通过重组MPZL2蛋白证实其可激活EGFR通路，促进肿瘤细胞侵袭和迁移，提示其作为潜在治疗靶点。
2. **文献名称**：*Structural Characterization of Recombinant Human MPZL2 and Its Role in Cell Adhesion*
**作者**：Li, X. et al. (2019)
**摘要**：本文成功在大肠杆菌中表达并纯化重组MPZL2蛋白，通过X射线晶体学解析其三维结构，功能实验表明其介导细胞间粘附，为理解其生理功能提供结构基础。
3. **文献名称**：*Association of MPZL2 Genetic Variants with Hearing Loss in Mouse Models*
**作者**：Wang, R. et al. (2021)
**摘要**：在小鼠模型中敲除Mpzl2基因导致耳蜗毛细胞退化及听力损伤，回补重组人MPZL2蛋白可部分恢复听觉功能，表明其在听觉系统中的关键作用。
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如需真实文献，建议检索PubMed、Web of Science等数据库，关键词："recombinant MPZL2" 或 "MPZL2 protein function"。
MPZL2 (Myelin Protein Zero-Like 2) is a transmembrane protein belonging to the immunoglobulin superfamily, primarily implicated in cell-cell adhesion and signaling. It shares structural homology with Myelin Protein Zero (MPZ), a critical component of myelin sheaths in peripheral nerves. MPZL2 is encoded by the MPZL2 gene located on human chromosome 11q23.3 and is expressed in various tissues, including the liver, immune cells, and epithelial tissues. Its extracellular domain contains immunoglobulin-like folds facilitating intercellular interactions, while the cytoplasmic domain may mediate intracellular signaling cascades.
Functionally, MPZL2 has been linked to immune regulation, cell migration, and tissue homeostasis. Studies suggest its involvement in modulating T-cell activation, inflammatory responses, and tumorigenesis. In the liver, it interacts with cell surface receptors to regulate metabolic pathways. Recent research highlights its potential role in cancer progression, with altered MPZL2 expression observed in hepatocellular carcinoma, breast cancer, and leukemia. Additionally, MPZL2 polymorphisms are associated with susceptibility to autoimmune diseases like rheumatoid arthritis.
Recombinant human MPZL2 protein, typically produced in mammalian expression systems, retains post-translational modifications crucial for functional studies. It serves as a valuable tool for investigating ligand-receptor interactions, signaling mechanisms, and therapeutic target validation. Despite growing interest, the full spectrum of MPZL2's biological roles and molecular partners remains under exploration, warranting further research into its pathophysiological significance.
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