| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | MOSPD3 |
| Uniprot No | O75425 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-235 aa |
| 活性数据 | MRRGAPQDQELVGPGPPGRGSRGAPPPLGPVVPVLVFPPDLVFRADQRSGPRQLLTLYNPTGTALRFRVLCTAPAKYTVFDAEGYVKPQSCIDIVIRHVAPIPSHYDVQDRFRIELSEEGAEGRVVGRKDITSILRAPAYPLELQGQPDPAPRPGPPAGTPPPTARHFQEHPRQQLATSSFLLFLLTGIVSVAFLLLPLPDELGSQLPQVLHVSLGQKLVAAYVLGLLTMVFLRT |
| 分子量 | 51.9 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人MOSPD3蛋白的3-4篇参考文献及其摘要概括(文献标题为虚拟示例)：
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1. **文献名称**：*MOSPD3 Promotes Monocyte Migration via Rac1/MAPK Signaling*
**作者**：Li R. et al.
**摘要**：本研究利用重组人MOSPD3蛋白，揭示了其在单核细胞趋化性和迁移中的关键作用。实验表明，MOSPD3通过激活Rac1和MAPK信号通路调控细胞骨架重组，提示其在炎症和免疫应答中的潜在功能。
2. **文献名称**：*Recombinant MOSPD3 Drives Cancer Metastasis by Modulating Integrin Signaling*
**作者**：Wang J. et al.
**摘要**：通过体外实验发现，重组MOSPD3蛋白可增强乳腺癌细胞的侵袭能力。机制研究表明，其通过结合整合素β1亚基激活FAK/Src通路，促进肿瘤转移，为靶向MOSPD3的癌症治疗提供依据。
3. **文献名称**：*Structural and Functional Analysis of MOSPD3 in Immune Regulation*
**作者**：Rodríguez M. et al.
**摘要**：通过解析重组MOSPD3蛋白的晶体结构，发现其C端结构域与免疫受体CD44存在特异性相互作用。功能实验显示MOSPD3可调节树突状细胞的成熟和抗原呈递，提示其在自身免疫疾病中的潜在角色。
4. **文献名称**：*MOSPD3 as a Serum Biomarker in Hepatocellular Carcinoma*
**作者**：Smith A. et al.
**摘要**：该研究利用重组MOSPD3蛋白建立ELISA检测方法，发现肝癌患者血清中MOSPD3水平显著升高，且与肿瘤分期和预后相关，提出其作为新型诊断标志物的可能性。
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注：以上文献为假设性示例，实际研究中建议通过PubMed、Web of Science等数据库检索具体文献(关键词：MOSPD3. recombinant protein, migration, cancer, immune)。
**Background of Recombinant Human MOSPD3 Protein**
MOTILE SPERM DOMAIN-CONTAINING PROTEIN 3 (MOSPD3), a member of the major facilitator superfamily (MFS), is a transmembrane protein encoded by the *MOSPD3* gene. It is characterized by four transmembrane domains and cytoplasmic N- and C-termini. MOSPD3 is implicated in regulating cell migration, particularly in immune responses, through its interaction with chemokine receptors such as CCR2. Studies suggest its role in monocyte recruitment and inflammatory processes, linking it to pathologies like cancer metastasis and autoimmune diseases (e.g., multiple sclerosis).
Recombinant human MOSPD3 protein is engineered using expression systems like HEK293 or CHO cells to ensure proper post-translational modifications. It often includes tags (e.g., His-tag, Fc-fusion) for purification and detection. This protein serves as a critical tool for studying MOSPD3’s molecular interactions, signaling pathways, and therapeutic potential. Inhibiting MOSPD3 has shown promise in preclinical models for reducing inflammation and tumor progression, highlighting its relevance as a drug target. Research continues to explore its dual role in immune regulation and disease mechanisms.
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