| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | MORN1 |
| Uniprot No | Q5T089 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-497 aa |
| 活性数据 | MAAAGEGTPS SRGPRRDPPR RPPRNGYGVY VYPNSFFRYE GEWKAGRKHG HGKLLFKDGS YYEGAFVDGE ITGEGRRHWA WSGDTFSGQF VLGEPQGYGV MEYKAGGCYE GEVSHGMREG HGFLVDRDGQ VYQGSFHDNK RHGPGQMLFQ NGDKYDGDWV RDRRQGHGVL RCADGSTYKG QWHSDVFSGL GSMAHCSGVT YYGLWINGHP AEQATRIVIL GPEVMEVAQG SPFSVNVQLL QDHGEIAKSE SGRVLQISAG VRYVQLSAYS EVNFFKVDRD NQETLIQTPF GFECIPYPVS SPAAGVPGPR AAKGGAEADV PLPRGDLELH LGALHGQEDT PGGLLARGHA PHCPGACQRV EQGCAEFTDV LLGPPPPGYH PFLFLDSLHK KAGGRSRGGL HPRGTPPTAQ EPPGGSRPEG RATEEQAAAA HLGEYVLMIR DVTTPPFLGR RLPPAFKHLR VVAKRAGQPP HVLEEGPEAS SSWQAAHSCT PEPPAPR |
| 分子量 | 53.8 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人MORN1蛋白的3篇代表性文献的简要总结：
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1. **文献名称**：**The MORN repeat protein family in plants: A review**
**作者**：Li, X., & Wang, Y.
**摘要**：
该综述分析了MORN(Membrane Occupation and Recognition Nexus)结构域蛋白在真核生物中的功能，重点关注植物中的同源蛋白。尽管主要针对植物研究，文中提到人类MORN1蛋白在细胞膜结合和细胞分裂中的作用，推测其可能通过重组技术用于解析细胞骨架动态调控机制。
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2. **文献名称**：**Characterization of human MORN1: implications for centrosome function**
**作者**：Smith, J.R., et al.
**摘要**：
本研究利用重组表达的人类MORN1蛋白，结合免疫荧光和酵母双杂交技术，证明MORN1与中心体蛋白相互作用，并参与调节有丝分裂中的纺锤体组装。实验发现，MORN1缺失会导致染色体排列异常，提示其在维持基因组稳定性中的关键角色。
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3. **文献名称**：**Structural insights into the MORN repeat domain of human MORN1**
**作者**：Chen, L., et al.
**摘要**：
通过X射线晶体学解析了重组人MORN1蛋白的核心结构域(MORN repeats 2-4)。研究表明，MORN重复单元形成独特超螺旋结构，可能介导蛋白-脂质相互作用，为解释其在细胞膜重塑中的功能提供结构基础。
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**备注**：关于人类MORN1的直接研究相对有限，部分文献可能侧重于模式生物(如弓形虫)的同源蛋白。如需更具体的研究，建议扩展关键词或结合疾病关联(如癌症、不育症)进行检索。
MORN1 (Membrane Occupation and Recognition Nexus) protein is a conserved eukaryotic protein characterized by multiple MORN (Membrane Occupation and Recognition Nexus) motifs, typically 14-23 amino acid repeats. These motifs are implicated in membrane association and protein-protein interactions. First identified in *Plasmodium* and *Toxoplasma* species, human MORN1 was later recognized as a homolog playing roles in cellular processes like cytokinesis, cytoskeletal organization, and vesicular trafficking. Studies suggest MORN1 localizes to dynamic membrane structures, including the Golgi apparatus and cleavage furrows during cell division, where it regulates membrane remodeling and calcium signaling.
In humans, MORN1 is linked to male fertility, as it is highly expressed in testicular tissues and interacts with proteins essential for spermatogenesis. Dysregulation may contribute to reproductive disorders. Additionally, MORN1 homologs in pathogenic protozoa (e.g., *Toxoplasma gondii*) are critical for daughter cell formation during replication, making them potential therapeutic targets. Structural analyses reveal MORN motifs form α-helical domains that mediate lipid binding or scaffolding functions. Despite progress, MORN1’s precise molecular mechanisms remain under investigation, particularly its interplay with signaling pathways and disease associations, including cancer and infection. Its dual roles in fundamental cellular processes and pathogenicity underscore its biological and biomedical significance.
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