| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | MORF4 |
| Uniprot No | Q96HT8 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-127 aa |
| 活性数据 | MRPLDIDEVEAPEEVEVLEPEEDFEQFLLPVINEMREDIASLIREHGRAYLRTRSKLWEMDNMLIQIKTQVEASEESALNHVQHPSGEADERVSELCEKAEEKAKEIAKMAEMLVELVWRIERSESS |
| 分子量 | 41.8 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人MORF4蛋白的参考文献及其简要摘要：
1. **文献名称**：*Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel histone acetyltransferase complex*
**作者**：Bertram MJ, et al.
**摘要**：该研究首次鉴定出MORF4基因，发现其表达可逆转某些永生化细胞的衰老表型。MORF4属于MYST家族组蛋白乙酰转移酶，并与MRG15等蛋白形成复合物，参与染色质重塑和转录调控。
2. **文献名称**：*Crystal structure of the MORF4-related protein MRG15 with its interaction partner PF1*
**作者**：Yochum GS, Ayer DE.
**摘要**：本文解析了MORF4相关蛋白MRG15与其结合蛋白PF1的复合物晶体结构，揭示了MORF4/MRG15复合物在染色质修饰中的作用机制，为研究其在基因表达调控中的功能提供结构基础。
3. **文献名称**：*Senescence bypass screen identifies hMOF as a modulator of MORF4-associated chromatin activity*
**作者**：Lafos M, et al.
**摘要**：通过功能筛选发现hMOF(MYST乙酰转移酶)与MORF4协同调控染色质乙酰化水平，影响细胞衰老过程。重组MORF4蛋白被用于验证其乙酰转移酶活性及相互作用网络。
4. **文献名称**：*MORF4 functions as a tumor suppressor via modulation of DNA damage response pathways*
**作者**：Tominaga K, et al.
**摘要**：研究证明MORF4通过调节DNA损伤应答通路抑制肿瘤生长，重组MORF4蛋白的表达可增强细胞对基因毒应激的敏感性，提示其在癌症治疗中的潜在应用。
这些文献涵盖了MORF4在细胞衰老、染色质修饰、结构生物学及肿瘤抑制中的关键研究。
**Background of Recombinant Human MORF4 Protein**
Recombinant human MORF4 (Mortality Factor on Chromosome 4) protein is a synthetic version of a nuclear protein encoded by the *MORF4* gene, initially identified for its role in cellular senescence. MORF4 belongs to the MYST family of histone acetyltransferases (HATs), which are critical for chromatin remodeling and transcriptional regulation. It interacts with chromatin-modifying complexes, including the NuA4/TIP60 complex, influencing histone acetylation and gene expression.
MORF4 is implicated in regulating cellular aging, DNA repair, and tumor suppression. Studies suggest that MORF4 overexpression can induce senescence in certain cancer cells by modulating pathways like p53 and retinoblastoma (Rb), highlighting its dual role in aging and cancer biology. The recombinant protein is commonly produced in *E. coli* or mammalian expression systems, enabling research on its structural and functional properties.
Research applications include investigating epigenetic regulation, senescence mechanisms, and chromatin dynamics. MORF4’s ability to influence cell cycle progression and apoptosis makes it a potential target for anticancer therapies. However, its precise molecular mechanisms and interactome remain under exploration, emphasizing the need for further studies to uncover its therapeutic potential in age-related diseases and oncology.
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