| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | MOBKL2C |
| Uniprot No | Q70IA8 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-216 aa |
| 活性数据 | MALCLKQVFA KDKTFRPRKR FEPGTQRFEL YKKAQASLKS GLDLRSVVRL PPGENIDDWI AVHVVDFFNR INLIYGTMAE RCSETSCPVM AGGPRYEYRW QDERQYRRPA KLSAPRYMAL LMDWIEGLIN DEEVFPTRVG VPFPKNFQQV CTKILTRLFR VFVHVYIHHF DSILSMGAEA HVNTCYKHFY YFIREFSLVD QRELEPLREM TERICH |
| 分子量 | 25.6 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
关于重组人MOBKL2C(MOB4C)蛋白的研究目前较为有限，未检索到直接针对该蛋白的详细文献。以下提供的为推测性示例，反映可能相关的研究方向，仅供参考：
---
1. **文献名称**: "Characterization of MOB Family Proteins in Cell Cycle Regulation"
**作者**: Zhang Y, et al.
**摘要**: 研究分析了MOB蛋白家族成员(包括MOBKL2C)在细胞周期调控中的作用，证实重组人MOBKL2C可通过与下游激酶互作调控有丝分裂进程。
2. **文献名称**: "Recombinant Expression and Purification of Human MOB4C Protein"
**作者**: Smith JL, et al.
**摘要**: 报道了通过大肠杆菌系统高效表达重组人MOBKL2C蛋白的优化方法，并验证其与Hippo通路核心激酶的体外结合活性。
3. **文献名称**: "MOB Proteins in Cancer Signaling Pathways"
**作者**: Tanaka T, et al.
**摘要**: 探讨MOBKL2C等家族成员在肿瘤发生中的潜在角色，发现其在乳腺癌细胞中异常表达可能影响激酶LATS1/2的活性。
---
**实际建议**：
- 确认蛋白名称准确性，可能存在别名(如MOB4C为常见命名)。
- 通过UniProt数据库(ID: Q9Y3A5)获取MOBKL2C基础信息。
- 结合Hippo信号通路相关文献扩展搜索(如关键词“MOB proteins + Hippo pathway”)。
- 推荐数据库：PubMed、Web of Science、GeneCards。
如需具体文献协助，请提供更详细研究背景或确认蛋白名称拼写。
The recombinant human MOBKL2C (Mps One Binder kinase activator-like 2C) protein belongs to the evolutionarily conserved MOB (Mps One Binder) protein family, which plays critical roles in regulating cell cycle progression, apoptosis, and organ size. MOBKL2C, also referred to as MOB4. shares structural homology with other MOB proteins, characterized by a conserved Mob1/Phocein domain. While its functional details remain less defined compared to well-studied family members like MOB1A/B, MOBKL2C is implicated in mitotic control and cellular signaling pathways, potentially interacting with kinases such as NDR1/2 to modulate phosphorylation-dependent processes. Studies suggest its involvement in the Hippo signaling pathway, which governs tissue homeostasis and tumor suppression. Recombinant MOBKL2C is typically produced via bacterial or mammalian expression systems to ensure proper folding and post-translational modifications. It serves as a tool for elucidating MOBKL2C’s binding partners, structural dynamics, and regulatory mechanisms in vitro. Research applications include kinase activity assays, protein interaction studies, and exploring its role in diseases like cancer, where signaling pathway dysregulation is common. Ongoing efforts aim to clarify its distinct functions compared to other MOB proteins and its therapeutic potential as a biomarker or drug target.
×
