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Recombinant Human MNX1 Protein

  • 中文名: 重组人(MNX1)蛋白
  • 别    名: HB 9; HB9; HLXB 9; HLXB9; Homeo box HB9; Homeobox HB9; Homeobox protein HB9; HOXHB9; MNX1; MNX1_HUMAN; Motor neuron and pancreas homeobox 1; Motor neuron and pancreas homeobox protein 1; Sacral agenesis autosomal dominant (Currarino triad); SCRA 1; SCRA1
货号: PA2000-9402
Price: ¥询价
数量:
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产品详情

纯度>90%SDS-PAGE.
种属Human
靶点MNX1
Uniprot NoP50219
内毒素< 0.01EU/μg
表达宿主E.coli
表达区间1-401 aa
活性数据MEKSKNFRID ALLAVDPPRA ASAQSAPLAL VTSLAAAASG TGGGGGGGGA SGGTSGSCSP ASSEPPAAPA DRLRAESPSP PRLLAAHCAL LPKPGFLGAG GGGGGTGGGH GGPHHHAHPG AAAAAAAAAA AAAAGGLALG LHPGGAQGGA GLPAQAALYG HPVYGYSAAA AAAALAGQHP ALSYSYPQVQ GAHPAHPADP IKLGAGTFQL DQWLRASTAG MILPKMPDFN SQAQSNLLGK CRRPRTAFTS QQLLELEHQF KLNKYLSRPK RFEVATSLML TETQVKIWFQ NRRMKWKRSK KAKEQAAQEA EKQKGGGGGA GKGGAEEPGA EELLGPPAPG DKGSGRRLRD LRDSDPEEDE DEDDEDHFPY SNGASVHAAS SDCSSEDDSP PPRPSHQPAP Q
分子量40.5 kDa
蛋白标签His tag N-Terminus
缓冲液0
稳定性 & 储存条件Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
复溶Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

参考文献

以下是关于重组人MNX1蛋白的3篇参考文献简述:

1. **"Functional characterization of recombinant human MNX1 protein in pancreatic β-cell development"**

*作者:Smith A, et al.*

摘要:研究通过大肠杆菌表达重组人MNX1蛋白,验证其促进胰岛素基因转录及胰腺β细胞分化的功能,证实MNX1通过结合特定DNA序列调控发育通路。

2. **"Purification and structural analysis of MNX1 homeodomain reveals DNA-binding specificity"**

*作者:Chen L, et al.*

摘要:利用昆虫细胞系统表达并纯化重组MNX1蛋白,结合X射线晶体学解析其结构,揭示其与靶基因结合的分子机制及关键氨基酸残基。

3. **"MNX1 as a therapeutic target in leukemogenesis: Insights from recombinant protein studies"**

*作者:Wang Y, et al.*

摘要:通过哺乳动物细胞表达重组MNX1.发现其异常激活可促进白血病细胞增殖,靶向抑制MNX1活性显著降低肿瘤生长,提示其作为治疗靶点的潜力。

(注:以上文献标题与内容为模拟简化示例,实际引用需以真实文献为准。)


背景信息

Motor neuron and pancreas homeobox 1 (MNX1), also known as Hb9. is a transcription factor encoded by the *MNX1* gene located on human chromosome 7q36.3. It belongs to the homeobox gene family, characterized by a conserved 60-amino-acid DNA-binding homeodomain that regulates gene expression during development. MNX1 plays pivotal roles in cell fate specification and differentiation, particularly in the nervous system and pancreas.

In the developing spinal cord, MNX1 is critical for the specification and maintenance of motor neurons, where it suppresses interneuron differentiation while promoting motor neuron identity through interactions with signaling pathways like Sonic Hedgehog (SHH). Beyond the nervous system, MNX1 is essential for pancreatic β-cell development and endocrine function. It regulates the maturation and functional identity of insulin-producing β-cells, influencing glucose homeostasis.

Clinically, MNX1 mutations are linked to congenital malformations such as sacral agenesis (currarino syndrome), characterized by spinal defects and anorectal anomalies, often combined with neonatal diabetes due to pancreatic dysgenesis. Autosomal dominant mutations, including deletions or truncating variants, disrupt its transcriptional regulatory function, leading to these multisystem disorders.

Current research focuses on MNX1’s regulatory networks in development, its role in diabetes pathogenesis, and its potential as a therapeutic target for motor neuron diseases or β-cell regeneration. Animal models, like *Mnx1*-deficient mice, recapitulate human phenotypes, underscoring its evolutionary conservation and functional importance.


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