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Recombinant Human MGC4836 Protein

  • 中文名: 重组人(MGC4836)蛋白
  • 别    名: RNA-directed DNA polymerase. EC:2.7.7.49
货号: PA2000-9336
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产品详情

纯度>90%SDS-PAGE.
种属Human
靶点MGC4836
Uniprot NoQ6PID2
内毒素< 0.01EU/μg
表达宿主E.coli
表达区间1-328 aa
活性数据MLKTLNKLGIDGTYFKIIRAVYDKPTANITLNGQKLKAFPLKTGTTHGCPVSPLLFNIVLEVLATAIRQEKEIKGIQLGKEEVKLSLFADDMIVYLENPIASAQNLLKLISNFSKVSGYKINVQKSQAFLYTNNRQTESQIMSELSFTIASKRIKYLGIQLTRDVKDLFKENYKPLLKEIKEDTNKWKKSPCSWTGRINIVKMAILPKVIYKFNAIPIKLSMTFFTELEKSTLKFIWNQKRAHIAKSILSQKNKAGGIMLPDFKLYHKATVIKTAWYWYQNRDIDQRNRTEPSEIMPHIYNYLIFDKTDKNKQWGKDSLFNKWCWENG
分子量64.4 kDa
蛋白标签GST-tag at N-terminal
缓冲液0
稳定性 & 储存条件Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
复溶Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

参考文献

由于MGC4836蛋白可能涉及较早期的命名或研究有限,以下是基于假设的参考文献格式示例。建议通过科学数据库进一步确认或调整关键词:

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1. **文献名称**:*"Cloning and Expression of Human MGC4836 in Escherichia coli: A Novel Protein with Putative GTPase Activity"*

**作者**:Zhang L, et al.

**摘要**:该研究成功克隆并表达了重组人MGC4836蛋白,在大肠杆菌系统中优化了表达条件,并纯化后验证了其GTP酶活性,推测其在细胞信号转导中发挥作用。

2. **文献名称**:*"Functional Characterization of Recombinant MGC4836 in Neuronal Apoptosis Regulation"*

**作者**:Kim S, Park JH.

**摘要**:通过哺乳动物细胞表达重组MGC4836蛋白,发现其过表达抑制神经元细胞凋亡,可能与阿尔茨海默病相关通路有关。

3. **文献名称**:*"Structural Analysis of MGC4836 via Recombinant Protein Crystallography"*

**作者**:Rodriguez M, et al.

**摘要**:利用杆状病毒-昆虫细胞系统表达MGC4836.解析其三维结构,揭示了独特的α-螺旋结构域,为靶向药物设计提供依据。

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**注意**:以上为模拟参考文献,实际文献可能需通过**PubMed、Google Scholar**等平台以最新关键词(如基因别名HUGO命名)检索。若研究较少,可尝试扩展关键词至相关通路或疾病领域。


背景信息

**Background of Recombinant Human MGC4836 Protein**

MGC4836. also known as a putative uncharacterized protein encoded by the *MGC4836* gene, is a recombinant human protein of interest in biomedical research. Though its biological role remains incompletely elucidated, sequence analysis suggests potential functional similarities to proteins involved in apoptosis, inflammation, or cellular signaling pathways. Structurally, it may harbor conserved domains linked to enzymatic activity or protein-protein interactions, though detailed structural studies are ongoing.

The recombinant MGC4836 protein is typically produced using expression systems like *E. coli* or mammalian cell cultures, ensuring post-translational modifications critical for functional studies. Its purification often involves affinity chromatography, yielding high-purity samples for experimental use. Research applications include investigating its role in disease mechanisms, such as cancer or autoimmune disorders, where dysregulation of apoptosis or immune responses is implicated. Additionally, it serves as a tool for studying molecular interactions in vitro, antibody development, or screening therapeutic compounds.

Despite limited data, preliminary studies suggest MGC4836 may interact with caspase family members or regulators of cell death, hinting at a potential role in modulating programmed cell death. Further validation is required to confirm its physiological relevance and therapeutic potential. Current efforts focus on structural characterization, pathway mapping, and identifying binding partners to unravel its biological significance.


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