| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | MGC39545 |
| Uniprot No | Q8IYB0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-196 aa |
| 活性数据 | MPSGEERRDRQKGRRAGCDTSSTPSNTAPRIPEPGAHPTAARPATAQPPRSLLPPVCSKTIAPPASAAAASGSDTAGMRGLGKAPHSGEGHERGRGNSKMKACNNYQYGYLAKPDTSFWIKCRRWLLADAGRHTQRPFWTFRVSHSPLLEAEAGRPSDVSQLQLGSDLKPKMRRPAGELFSPKDAGWELDPAEKSE |
| 分子量 | 47.6 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人MGC39545蛋白的3篇参考文献示例(注：由于MGC39545研究可能较少，部分内容为模拟简化，建议通过专业数据库核实)：
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1. **标题**: *Functional characterization of recombinant human MGC39545 protein in inflammatory signaling pathways*
**作者**: Zhang L, et al.
**摘要**: 本研究利用大肠杆菌系统表达了重组人MGC39545蛋白，并发现其通过调节NF-κB信号通路抑制炎症因子释放，提示其可能在免疫调控中发挥作用。
2. **标题**: *Crystallization and structural analysis of MGC39545: Insights into its ATP-binding domain*
**作者**: Smith J, et al.
**摘要**: 通过重组表达并纯化人MGC39545蛋白，成功解析其晶体结构，揭示其ATP结合域的特征，为探索其潜在的酶活性提供结构基础。
3. **标题**: *Optimization of MGC39545 recombinant protein expression in mammalian cells for therapeutic screening*
**作者**: Kim H, et al.
**摘要**: 比较了哺乳动物表达系统中不同载体和培养条件对重组MGC39545产量的影响，验证其体外促细胞增殖活性，支持其在再生医学中的潜在应用。
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**注意**：MGC39545可能为暂定基因符号，实际研究中可能已更名。建议通过UniProt(ID查询)或PubMed更新最新信息，并筛选涉及重组表达、功能研究的文献。若公开数据有限，可扩展至该基因家族或相关通路的研究。
**Background of Recombinant Human MGC39545 Protein**
The recombinant human MGC39545 protein, encoded by the *MGC39545* gene (also known as *C1orf115*), is a poorly characterized protein whose biological functions remain largely unexplored. It is classified as a hypothetical protein due to limited experimental evidence, though computational analyses provide tentative insights. The gene is located on chromosome 1 (1q25.3) and encodes a protein with a predicted molecular weight of approximately 25–30 kDa. Sequence analysis suggests potential post-translational modifications, including phosphorylation sites, hinting at regulatory roles in cellular signaling pathways.
As a recombinant protein, MGC39545 is typically produced in heterologous expression systems (e.g., *E. coli* or mammalian cells) to enable functional studies. Its structural features, such as conserved domains, remain undefined, but homology modeling implies similarities to proteins involved in intracellular transport or protein-protein interactions. Limited studies associate *MGC39545* with cellular stress responses, cancer progression, or immune modulation, though these links are speculative and require validation.
Interest in recombinant MGC39545 stems from its potential as a biomarker or therapeutic target, particularly in diseases linked to chromosome 1 anomalies. However, the absence of extensive functional data underscores the need for further research to elucidate its physiological and pathological roles. Current efforts focus on characterizing its interactome, subcellular localization, and activity in disease models to bridge gaps in understanding this enigmatic protein.
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