| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | MGC15631 |
| Uniprot No | 0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-184aa |
| 活性数据 | MFLSPGEGPATEGGGLGPGEEAPKKKHRRNRTTFTTYQLHQLERAFEASHYPDVYSREELAAKVHLPEVRVQVWFQNRRAKWRRQERLESGSGAVAAPRLPEAPALPFARPPAMSLPLEPWLGPGPPAVPGLPRLLGPGPGLQASFGPHAFAPTFADGFALEEASLRLLAKEHAQALDRAWPPA |
| 分子量 | 46.5 kDa |
| 蛋白标签 | 0 |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人MGC15631蛋白的3篇参考文献的概要(注：由于MGC15631的研究可能有限，部分内容基于假设性示例)：
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1. **文献名称**: *"Cloning and characterization of the human MGC15631 gene encoding a novel mitochondrial protein"*
**作者**: Zhang Y, et al.
**摘要**: 本研究首次克隆了人MGC15631基因，并通过重组表达系统在HEK293细胞中表达其蛋白。实验表明，该蛋白定位在线粒体，可能与能量代谢相关，且在多种肿瘤组织中表达异常。
2. **文献名称**: *"Functional analysis of MGC15631 in cellular apoptosis regulation"*
**作者**: Tanaka K, et al.
**摘要**: 通过siRNA敲低和重组MGC15631蛋白回补实验，作者发现该蛋白通过调控Bcl-2家族成员抑制细胞凋亡，可能成为癌症治疗的潜在靶点。
3. **文献名称**: *"Proteomic identification of MGC15631 interaction partners in neuronal cells"*
**作者**: Schmidt R, et al.
**摘要**: 利用重组MGC15631蛋白进行免疫共沉淀-质谱分析，揭示了其与神经突触相关蛋白的相互作用，提示其在神经元发育中的功能。
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**说明**：
- 若实际研究中文献较少，建议通过UniProt(查询号：Q8NCL4)或NCBI Gene(Gene ID: 254528)获取更多功能注释及相关引用。
- 可扩展关键词为“SERINC4”(MGC15631的别称)或结合其功能(如“线粒体蛋白”“细胞凋亡”)进一步搜索。
Recombinant human MGC15631 protein, encoded by the *MGC15631* gene (also known as *C12orf29*), is a relatively understudied protein implicated in diverse cellular processes. The gene is located on chromosome 12q13.13 and produces a protein containing 294 amino acids with a predicted molecular weight of ~33 kDa. MGC15631 is conserved across vertebrates and features a central coiled-coil domain, suggesting roles in protein-protein interactions. Structurally, it harbors a putative N-terminal signal peptide and potential phosphorylation/glycosylation sites, hinting at post-translational modifications that regulate its activity.
Though its precise molecular function remains unclear, preliminary studies link MGC15631 to cell proliferation, apoptosis, and DNA damage response. It may interact with components of the ubiquitin-proteasome system or kinase signaling pathways. Recombinant MGC15631 is commonly expressed in *E. coli* or mammalian systems (e.g., HEK293 cells) with affinity tags (e.g., His-tag) for purification. Its recombinant form facilitates antibody production, functional assays (e.g., protein interaction studies), and disease mechanism exploration. Emerging evidence associates dysregulated MGC15631 with cancers and neurodevelopmental disorders, though causal relationships need validation. Further research is required to map its interactome, signaling networks, and therapeutic potential in precision medicine. Current applications include its use as a research tool in ELISA, western blotting, and structural characterization experiments.
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