| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | MGC12981 |
| Uniprot No | B8ZZ99 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-132 aa |
| 活性数据 | MGAKSVGPLQYASHMEPQVCLHASEAQEGLQKFKVVRAGVHAPEEVGPREAGLRRRKGPTKTPEPESSEAPQDPLNWFGILVPHSLRQAQASFRDGLQLAADIASLQNRIDWGRSQLRGLQEKLKQLEPGAA |
| 分子量 | 40.26 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人MGC12981蛋白的参考文献示例(部分文献可能为虚构或代指性描述，建议通过实际数据库核实)：
1. **文献名称**: "Functional characterization of recombinant human MGC12981 protein in cell adhesion"
**作者**: Smith A, et al.
**摘要**: 本研究通过在大肠杆菌中表达重组MGC12981蛋白，发现其通过调控整合素信号通路促进细胞黏附，暗示其在组织修复中的潜在作用。
2. **文献名称**: "Structural analysis of MGC12981 reveals a novel calcium-binding domain"
**作者**: Lee C, et al.
**摘要**: 利用X射线晶体学解析MGC12981的三维结构，发现其含有一个新型钙离子结合域，推测与细胞内钙信号传导相关。
3. **文献名称**: "MGC12981 overexpression inhibits tumor metastasis via EMT pathway suppression"
**作者**: Wang X, et al.
**摘要**: 通过体外实验证实，重组MGC12981过表达可抑制上皮间质转化(EMT)，降低乳腺癌细胞的迁移能力，提示其作为肿瘤治疗靶点的潜力。
4. **文献名称**: "MGC12981 interacts with mitochondrial proteins: implications for cellular energy metabolism"
**作者**: Gonzalez R, et al.
**摘要**: 采用免疫共沉淀技术发现MGC12981与线粒体ATP合成酶复合物相互作用，可能通过调节能量代谢影响细胞凋亡过程。
**注意事项**：
- MGC12981(现可能重新命名为 **C1orf123** 或其他符号)研究较少，上述文献为模拟示例，实际需通过 **PubMed/UniProt** 查询最新进展。
- 建议结合基因别名或最新命名(如HGNC数据库)扩大检索范围。
**Background of Recombinant Human MGC12981 Protein**
The recombinant human MGC12981 protein is a product of the *MGC12981* gene, a poorly characterized gene initially identified through large-scale sequencing efforts as part of the Mammalian Gene Collection (MGC). This gene is thought to encode a protein with potential functional roles in cellular processes, though its precise biological mechanisms remain understudied. Structurally, MGC12981 is predicted to contain conserved domains suggestive of involvement in protein-protein interactions or enzymatic activity, though detailed structural analyses are limited.
Recombinant production of MGC12981 typically involves expression in heterologous systems like *E. coli* or mammalian cell lines, enabling biochemical and functional studies. Its recombinant form is purified for use in experimental assays, such as elucidating its interaction partners, subcellular localization, or role in signaling pathways. While direct links to specific diseases are not yet established, MGC12981 has been occasionally cited in omics studies, hinting at possible associations with cancer or metabolic disorders. Current research focuses on unraveling its physiological relevance, leveraging recombinant protein tools to explore its contributions to cellular homeostasis, stress responses, or disease pathogenesis. Further studies are needed to validate its molecular functions and therapeutic potential.
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