| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | MAS1L |
| Uniprot No | P35410 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-378aa |
| 活性数据 | MVWGKICWFSQRAGWTVFAESQISLSCSLCLHSGDQEAQNPNLVSQLCGVFLQNETNETIHMQMSMAVGQQALPLNIIAPKAVLVSLCGVLLNGTVFWLLCCGATNPYMVYILHLVAADVIYLCCSAVGFLQVTLLTYHGVVFFIPDFLAILSPFSFEVCLCLLVAISTERCVCVLFPIWYRCHRPKYTSNVVCTLIWGLPFCINIVKSLFLTYWKHVKACVIFLKLSGLFHAILSLVMCVSSLTLLIRFLCCSQQQKATRVYAVVQISAPMFLLWALPLSVAPLITDFKMFVTTSYLISLFLIINSSANPIIYFFVGSLRKKRLKESLRVILQRALADKPEVGRNKKAAGIDPMEQPHSTQHVENLLPREHRVDVET |
| 分子量 | 42,4 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人MAS1L蛋白的3篇代表性文献（虚构示例，仅供格式参考）：
1. **文献名称**：*Expression and Functional Analysis of Recombinant Human MAS1L in Angiotensin Signaling*
**作者**：Zhang Y, et al.
**摘要**：研究通过哺乳动物细胞系统表达了重组人MAS1L蛋白，发现其作为孤儿G蛋白偶联受体，可通过抑制血管紧张素II受体1（AT1R）的活性调节心血管功能，为高血压治疗提供新靶点。
2. **文献名称**：*Structural Insights into MAS1L Receptor and Its Interaction with Ligands*
**作者**：Li H, et al.
**摘要**：解析了重组MAS1L蛋白的晶体结构，揭示其跨膜结构域独特构象，并通过体外结合实验鉴定了潜在内源性配体，为设计靶向MAS1L的药物奠定基础。
3. **文献名称**：*Recombinant MAS1L Attenuates Fibrosis in Murine Models via ERK Pathway Modulation*
**作者**：Wang J, et al.
**摘要**：在小鼠肺纤维化模型中，外源重组MAS1L蛋白显著抑制胶原沉积，机制研究表明其通过调控ERK信号通路减少成纤维细胞活化，提示其抗纤维化治疗潜力。
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**备注**：以上文献为示例，实际研究中建议通过PubMed、Web of Science等平台以“recombinant MAS1L”或“MAS1L protein function”为关键词检索近期论文。可关注领域内权威期刊如*Nature Communications*、*Cell Reports*等。
Recombinant human MAS1L protein is a genetically engineered variant derived from the MAS1 oncogene, a class of G protein-coupled receptors (GPCRs) primarily associated with cell signaling regulation. The MAS1 gene encodes the angiotensin receptor MAS1, which interacts with angiotensin-(1-7) and modulates cardiovascular, pulmonary, and metabolic functions. MAS1L, a truncated isoform of MAS1, lacks the seven-transmembrane domains characteristic of GPCRs, existing instead as a soluble receptor. This structural divergence suggests a distinct functional role, potentially involving ligand binding or modulation of signaling pathways linked to inflammation, fibrosis, or cell proliferation.
Research on MAS1L remains limited, but its recombinant form has gained attention as a tool for elucidating its biological mechanisms. Produced via expression systems like *E. coli* or mammalian cells, recombinant MAS1L is purified to study interactions with ligands, receptors (e.g., ACE2), or intracellular partners. Emerging studies propose its involvement in pathological processes, including cancer progression and organ injury, possibly through crosstalk with the renin-angiotensin system (RAS). However, its precise physiological role and therapeutic potential remain speculative. Current applications focus on *in vitro* assays, antibody development, and exploring its utility as a biomarker or therapeutic target for diseases like hypertension or fibrosis. Challenges include resolving its structural dynamics and validating *in vivo* relevance, necessitating further functional and clinical investigations.
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