| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | MAGEL2 |
| Uniprot No | Q9UJ55 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-646aa |
| 活性数据 | MEFQEVQQTQALAWQAQKAPTHIWQPLPAQEAQRQAPPLVQLEQPFQGAPPSQKAVQIQLPPQQAQASGPQAEVPTLPLQPSWQAPPAVLQAQPGPPVAAANFPLGSAKSLMTPSGECRASSIDRRGSSKERRTSSKERRAPSKDRMIFAATFCAPKAVSAARAHLPAAWKNLPATPETFAPSSSVFPATSQFQPASLNAFKGPSAASETPKSLPYALQDPFACVEALPAVPWVPQPNMNASKASQAVPTFLMATAAAPQATATTQEASKTSVEPPRRSGKATRKKKHLEAQEDSRGHTLAFHDWQGPRPWENLNLSDWEVQSPIQVSGDWEHPNTPRGLSGWEGPSTSRILSGWEGPSASWALSAWEGPSTSRALGLSESPGSSLPVVVSEVASVSPGSSATQDNSKVEAQPLSPLDERANALVQFLLVKDQAKVPVQRSEMVKVILREYKDECLDIINRANNKLECAFGYQLKEIDTKNHAYIIINKLGYHTGNLVASYLDRPKFGLLMVVLSLIFMKGNCVREDLIFNFLFKLGLDVRETNGLFGNTKKLITEVFVRQKYLEYRRIPYTEPAEYEFLWGPRAFLETSKMLVLRFLAKLHKKDPQSWPFHYLEALAECEWEDTDEDEPDTGDSAHGPTSRPPPR |
| 分子量 | 71.1 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人MAGEL2蛋白的3篇代表性文献的简明摘要：
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1. **文献名称**：*MAGEL2 regulates autophagy in Prader-Willi syndrome through ubiquitin-dependent pathways*
**作者**：Soni, R., et al.
**摘要**：研究通过重组人MAGEL2蛋白在细胞模型中的功能实验，揭示其通过调控泛素-蛋白酶体系统影响自噬进程，解释了其在普拉德-威利综合征中导致代谢异常的可能机制。
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2. **文献名称**：*Expression and functional characterization of recombinant human MAGEL2 in neuronal development*
**作者**：Yang, J., et al.
**摘要**：利用重组MAGEL2蛋白进行体外神经细胞分化实验，发现其通过激活TRIM27/RNF途径促进神经元成熟，为神经发育障碍的分子机制提供了新见解。
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3. **文献名称**：*Structural insights into the MAGEL2 protein: Implications for its role in circadian rhythm regulation*
**作者**：Dittmer, T.A., et al.
**摘要**：通过重组蛋白晶体结构解析，发现MAGEL2的MAGE结构域特异性结合昼夜节律相关蛋白，阐明其在生物钟调控中的潜在作用。
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注：上述文献为假设性示例，具体研究需参考真实发表的学术论文。建议通过PubMed或Google Scholar以“recombinant human MAGEL2”为关键词检索最新成果。
Recombinant human MAGEL2 protein is a genetically engineered form of the MAGEL2 protein, encoded by the *MAGEL2* gene located in the Prader-Willi syndrome (PWS) critical region on chromosome 15q11-q13. MAGEL2 belongs to the MAGE (melanoma antigen gene) family, which is implicated in neurodevelopment, ubiquitination pathways, and cellular regulation. The gene is maternally imprinted and paternally expressed, with loss-of-function mutations or deletions linked to PWS and Schaaf-Yang syndrome, disorders characterized by developmental delays, hypotonia, and endocrine dysfunctions. MAGEL2 is highly expressed in neuronal tissues, particularly the hypothalamus, where it interacts with TRIM27 and regulates endosomal trafficking and retrograde signaling. Recombinant MAGEL2 is produced in vitro (e.g., bacterial or mammalian systems) to study its biochemical properties, interactions, and therapeutic potential. Research focuses on understanding its role in ubiquitin ligase complex formation, protein degradation, and neuronal survival pathways. Such studies aim to elucidate molecular mechanisms underlying PWS-related pathologies and explore strategies for targeted interventions. Its recombinant form enables in vitro assays, structural analysis, and screening for modulators to address MAGEL2-associated disorders.
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