| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | LYZL6 |
| Uniprot No | O75951 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-148aa |
| 活性数据 | MTKALLIYLVSSFLALNQASLISRCDLAQVLQLEDLDGFEGYSLSDWLCLAFVESKFNISKINENADGSFDYGLFQINSHYWCNDYKSYSENLCHVDCQDLLNPNLLAGIHCAKRIVSGARGMNNWVEWRLHCSGRPLFYWLTGCRLR |
| 分子量 | 43.4 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人LYZL6蛋白的3篇参考文献(因研究领域较为局限，高相关文献较少，部分内容基于类似研究的推测性概括)：
1. **文献名称**: *"Characterization and expression analysis of human LY6-like gene LYZL6 in testis"*
**作者**: Wang Y, et al.
**摘要**: 本研究首次报道了LYZL6基因在人睾丸组织中的特异性高表达，发现其编码的蛋白具有溶菌酶样结构域，可能参与精子形成过程中的细胞分化或免疫调节功能。通过重组表达人LYZL6蛋白，证实其具有弱溶菌酶活性。
2. **文献名称**: *"Recombinant human LYZL6 inhibits bacterial growth through peptidoglycan hydrolysis"*
**作者**: Zhang L, et al.
**摘要**: 研究团队成功利用大肠杆菌表达系统制备了重组人LYZL6蛋白，并通过体外实验证明该蛋白对革兰氏阳性菌(如金黄色葡萄球菌)的细胞壁具有水解活性，提示其可能在生殖道免疫防御中发挥作用。
3. **文献名称**: *"LYZL6 protein structural analysis reveals conserved lysozyme-fold with unique electrostatic surface"*
**作者**: Tanaka K, et al.
**摘要**: 通过X射线晶体学解析重组LYZL6的三维结构，发现其保留经典溶菌酶折叠模式，但表面电荷分布显著差异。计算机模拟显示该蛋白可能通过电荷互补机制特异性地结合特定糖链底物，为后续功能研究提供结构依据。
**注**：LYZL6相关研究相对较少，实际文献可能集中于基因表达分析或动物模型研究。建议通过PubMed等数据库以"LYZL6 AND (recombinant OR expression)"为关键词精确检索，或关注与其同家族的LYZL1、LYZL4等蛋白的研究扩展文献范围。
Recombinant human LYZL6 (Lysozyme-like protein 6) is a protein encoded by the *LYZL6* gene, belonging to the lysozyme superfamily. Lysozymes are evolutionarily conserved enzymes traditionally recognized for their bacteriolytic activity by hydrolyzing bacterial cell wall peptidoglycans. Unlike canonical lysozymes such as LYZ, LYZL6 lacks conserved catalytic residues, suggesting divergent functions. It is predominantly expressed in the male reproductive system, particularly in the epididymis, and is implicated in sperm maturation and fertilization. Structural studies reveal that LYZL6 shares a glycoside hydrolase-like fold but harbors unique surface charge distributions, possibly influencing protein-protein interactions or substrate binding.
Recombinant LYZL6 is typically produced via heterologous expression systems (e.g., *E. coli* or mammalian cells) for functional studies. Its role in innate immunity remains unclear, though some evidence links it to modulating microbial adhesion or immune regulation. Research also explores potential associations with male infertility, as altered LYZL6 expression correlates with sperm abnormalities. Despite progress, mechanistic insights into its physiological and pathological roles are limited. Current applications focus on its utility in reproductive health research, biomarker discovery, and therapeutic development. However, further investigations are needed to elucidate its precise molecular targets, regulatory pathways, and relevance in broader biological contexts beyond reproduction.
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