| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | LY6G5B |
| Uniprot No | Q8NDX9 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-201aa |
| 活性数据 | MKVHMLVGVLVMVGFTVGKVPVPDIRTCHFCLVEDPSVGCISGSEKCTISSSSLCMVITIYYDVKVRFIVRGCGQYISYRCQEKRNTYFAEYWYQAQCCQYDYCNSWSSPQLQSSLPEPHDRPLALPLSDSQIQWFYQALNLSLPLPNFHAGTEPDGLDPMVTLSLNLGLSFAELRRMYLFLNSSGLLVLPQAGLLTPHPS |
| 分子量 | 49 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是为您模拟的3篇关于重组人LY6G5B蛋白的参考文献示例(请注意，这些文献为虚构创作，实际研究请通过学术数据库核实)：
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1. **文献名称**：*Cloning and Functional Analysis of Recombinant Human LY6G5B Protein in Immune Regulation*
**作者**：Chen X, Li R, Wang M
**摘要**：研究利用哺乳动物表达系统成功表达重组人LY6G5B蛋白，并发现其通过调节T细胞受体信号通路抑制炎症因子释放，提示其在自身免疫性疾病中的潜在治疗作用。
2. **文献名称**：*Structural Characterization of LY6G5B and Its Interaction with PD-L1*
**作者**：Johnson T, et al.
**摘要**：采用冷冻电镜技术解析了LY6G5B蛋白的三维结构，发现其通过结合PD-L1阻断肿瘤免疫逃逸，为开发新型免疫检查点抑制剂提供依据。
3. **文献名称**：*LY6G5B as a Prognostic Marker in Gastric Cancer: Insights from Recombinant Protein-Based Assays*
**作者**：Tanaka K, et al.
**摘要**：通过重组LY6G5B蛋白开发ELISA检测方法，证实其在胃癌患者血清中高表达，且与肿瘤转移及预后不良显著相关。
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**建议**：如需真实文献，可通过以下关键词在PubMed或Google Scholar检索：
`"recombinant human LY6G5B"`, `"LY6G5B protein function"`, `"LY6G5B immune"`，并注意可能的别名(如LY6家族其他成员)。
The recombinant human LY6G5B protein is derived from the LY6G5B gene, a member of the Ly-6/uPAR superfamily characterized by conserved LU domain structures. This protein is a glycosylphosphatidylinositol (GPI)-anchored cell surface molecule predominantly expressed in immune-related tissues, including the spleen and lymph nodes. LY6G5B shares structural homology with other LY6 family members involved in immune regulation, cell adhesion, and signal transduction, though its precise biological function remains under investigation.
Emerging studies suggest potential roles in modulating immune responses, particularly in T-cell activation and inflammation. Altered LY6G5B expression has been observed in cancers, including colorectal and esophageal malignancies, implying possible links to tumorigenesis or immune evasion. Its restricted tissue expression and membrane localization make it a candidate biomarker or therapeutic target.
Recombinant LY6G5B is typically produced using mammalian expression systems (e.g., HEK293 or CHO cells) to ensure proper post-translational modifications. Purification often employs affinity tags for research applications like antibody development, protein interaction assays, and functional studies. Current research focuses on clarifying its ligands, downstream signaling pathways, and therapeutic potential in autoimmune diseases and oncology. The development of recombinant LY6G5B facilitates mechanistic studies to unravel its physiological and pathological significance.
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