| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | LUZP6 |
| Uniprot No | Q538Z0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-435aa |
| 活性数据 | MAQAVWSRLGRILWLACLLPWAPAGVAAGLYELNLTTDSPATTGAVVTISASLVAKDNGSLALPADAHLYRFHWIHTPLVLTGKMEKGLSSTIRVVGHVPGEFPVSVWVTAADCWMCQPVARGFVVLPITEFLVGDLVVTQNTSLPWPSSYLTKTVLKVSFLLHDPSNFLKTALFLYSWDFGDGTQMVTEDSVVYYNYSIIGTFTVKLKVVAEWEEVEPDATRAVKQKTGDFSASLKLQETLRGIQVLGPTLIQTFQKMTVTLNFLGSPPLTVCWRLKPECLPLEEGECHPVSVASTAYNLTHTFRDPGDYCFSIRAENIISKTHQYHKIQVWPSRIQPAVFAFPCATLITVMLAFIMYMTLRNATQQKDMVEVADFDFSPMSDKNPEPPSGVRCCCQMCCGPFLLETPSEYLEIVRENHGLLPPLYKSVKTYTV |
| 分子量 | 74.25 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
关于重组人LUZP6蛋白的研究目前较少，公开文献可能较为有限。以下是基于该蛋白已知功能的模拟参考文献示例(非真实存在，仅供格式参考)：
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1. **"Expression and Purification of Recombinant Human LUZP6 for Structural Analysis"**
*Author: Chen L, et al.*
**摘要**：本研究报道了在HEK293细胞中重组表达人源LUZP6蛋白的优化方法，通过亲和层析和尺寸排阻色谱纯化获得高纯度蛋白，并利用圆二色谱分析其二级结构，为后续功能研究奠定基础。
2. **"LUZP6 Interaction with Microtubules: Implications in Neuronal Development"**
*Author: Watanabe S, et al.*
**摘要**：通过免疫共沉淀和共聚焦显微术，发现重组人LUZP6蛋白与微管网络存在直接相互作用，并可能通过调控微管动态影响神经元轴突的形成。
3. **"Functional Screening of LUZP6 Variants Using Recombinant Protein Assays"**
*Author: Gupta R, et al.*
**摘要**：构建了LUZP6的重组突变体文库，通过体外结合实验揭示了其羧酸酯酶结构域在细胞周期调控中的关键作用，暗示其与癌症基因变异的潜在关联。
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**说明**：由于LUZP6研究尚处于早期阶段，实际文献可能较少。建议通过以下途径获取最新信息：
- 使用PubMed或Google Scholar搜索 **"recombinant LUZP6 protein"** 或 **"LUZP6 function"**;
- 查阅细胞骨架或神经元发育相关领域的高分期刊(如*J Cell Biol*, *Cell Reports*)。
**Background of Recombinant Human LUZP6 Protein**
The leucine zipper protein 6 (LUZP6), also known as LZTS2. is a member of the leucine zipper tumor suppressor family, implicated in cellular processes such as cytoskeletal organization, cell division, and signal transduction. LUZP6 contains conserved leucine-rich repeats and a C-terminal leucine zipper domain, suggesting roles in protein-protein interactions and potentially modulating transcription or structural functions. Dysregulation of LUZP6 has been loosely associated with cancer progression and neurodevelopmental disorders, though its precise mechanistic roles remain under investigation.
Recombinant human LUZP6 protein is engineered using biotechnological platforms (e.g., *E. coli* or mammalian expression systems) to produce purified, functionally active protein for research. Its recombinant form enables studies on LUZP6’s interactions, structural properties, and regulatory functions in vitro or in cellular models. Current research focuses on elucidating its involvement in ciliogenesis, Wnt signaling, and microtubule dynamics, with potential links to diseases like intellectual disability and cancer metastasis.
Despite limited characterization compared to other LZTS family members (e.g., LUZP1), recombinant LUZZP6 serves as a critical tool for unraveling its biological significance, offering avenues for therapeutic targeting or biomarker discovery in associated pathologies. Further studies are needed to map its interactome and define its pathophysiological relevance.
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