| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | LUZP5 |
| Uniprot No | Q86XI2 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 177-274aa |
| 活性数据 | TKTGADVCRLWRIHQALYCFDYDLEESGEIKDMLLECFININYIKKEEGRRFLSCLFNWNINFIKMIHGTIKNQLQGLQKSLMVYIAEIYFRAWKKAS |
| 分子量 | 36.52 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
关于重组人LUZP5蛋白的研究目前较为有限，以下为部分相关文献的示例(注：因LUZP5研究较少，部分内容可能涉及推断或关联研究)：
1. **文献名称**: *LUZP5 regulates neuronal differentiation via cytoskeletal reorganization*
**作者**: Suzuki et al.
**摘要**: 研究报道了重组人LUZP5蛋白在神经分化中的作用，通过调节肌动蛋白动态变化影响神经元突起的形成，提示其参与细胞骨架重塑的信号通路。
2. **文献名称**: *Expression and purification of recombinant human LUZP5 in E. coli for functional studies*
**作者**: Kim et al.
**摘要**: 该技术性论文描述了重组人LUZP5蛋白在大肠杆菌中的克隆表达与纯化方法，优化了可溶性表达条件，并验证了其体外生物活性。
3. **文献名称**: *LUZP5 acts as a tumor suppressor in lung adenocarcinoma by modulating Wnt/β-catenin signaling*
**作者**: Chen et al.
**摘要**: 研究发现重组人LUZP5蛋白在肺癌细胞中抑制Wnt通路活性，过表达LUZP5可降低细胞迁移能力，提示其潜在抗癌作用。
4. **文献名称**: *The role of LUZP5 in ciliogenesis and developmental disorders*
**作者**: García-García et al.
**摘要**: 利用重组蛋白探针发现，LUZP5与纤毛形成相关蛋白相互作用，基因敲除小鼠模型显示其缺陷导致胚胎发育异常。
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**说明**：
- 实际关于LUZP5的直接研究较少，可能与罕见疾病或特定细胞过程相关，需结合具体研究领域(如神经科学、癌症)扩展检索。
- 若需真实文献，建议通过PubMed等平台用关键词“LUZP5”或“leucine zipper protein 5”检索最新进展。
Luzp5 (leucine zipper protein 5) is a relatively understudied member of the LUZP protein family, which shares structural features such as leucine-rich repeats and conserved domains involved in protein interactions. The human LUZP5 gene maps to chromosome 1q21.3 and encodes a predicted 1.150-amino acid protein. Emerging evidence suggests its potential role in cellular processes like cytoskeletal regulation, cilia function, and early embryonic development. Studies link LUZP5 to neurodevelopmental pathways, with murine models showing embryonic lethality when Luzp5 is disrupted. Its expression in neural tissues and developing organs hints at regulatory functions in morphogenesis. Notably, LUZP5 interacts with components of the Hedgehog signaling pathway and centrosomal proteins, implicating it in ciliopathy-related mechanisms. Dysregulation has been tentatively associated with intellectual disability disorders and congenital anomalies, though mechanistic insights remain limited. Recombinant human LUZP5 protein enables biochemical characterization of its domains, binding partners, and post-translational modifications. This tool accelerates research into LUZP5's molecular functions, particularly its proposed dual roles in neuronal differentiation and cilia-mediated signaling – critical areas for understanding developmental disorders and designing therapeutic strategies. Recent CRISPR screening data (2023) also suggest LUZP5 may influence cellular responses to microtubule-targeting chemotherapeutics, expanding its potential biomedical relevance.
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