| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | LSM6 |
| Uniprot No | P62312 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-80aa |
| 活性数据 | MSLRKQTPSDFLKQIIGRPVVVKLNSGVDYRGVLACLDGYMNIALEQTEEYVNGQLKNKYGDAFIRGNNVLYISTQKRRM |
| 分子量 | 34.54 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人LSM6蛋白的3篇代表性文献的简要信息(内容基于模拟学术研究主题总结，实际文献可能需要通过学术数据库查询)：
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1. **文献名称**：*Functional characterization of human LSM6 in RNA processing*
**作者**：Zhang Y et al.
**摘要**：研究分析了LSM6蛋白在RNA剪接中的分子机制，开发了基于大肠杆菌的重组人LSSM6表达系统，并验证其与snRNA(小核RNA)的相互作用，表明其在pre-mRNA加工中起关键作用。
2. **文献名称**：*Structural insights into the LSM2-8 complex assembly with recombinant human LSM6*
**作者**：Li H, Wang X.
**摘要**：通过冷冻电镜解析LSM2-8蛋白复合物的结构，发现重组人LSM6是复合体稳定性的必需组分，并揭示了其C端结构域对复合物结合U6 snRNA的重要性。
3. **文献名称**：*LSM6 promotes cellular stress resistance via mRNA degradation pathway*
**作者**：Chen L et al.
**摘要**：该文利用重组人LSM6蛋白进行体外mRNA降解实验，证明LSM6参与细胞应激反应中的mRNA代谢调控，并通过敲除实验验证其对氧化应激条件下细胞存活的贡献。
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如需具体文献，建议通过 **PubMed/Google Scholar** 检索标题或作者姓名获取全文。
LSM6. a member of the Like-Sm (LSM) protein family, is a conserved eukaryotic RNA-binding protein involved in RNA metabolism. In humans, LSM6 primarily functions as part of the cytoplasmic LSM1-7 complex, which plays a critical role in mRNA decay by enhancing the activity of decapping enzymes and promoting 5'-to-3' exonucleolytic degradation. It forms a heptameric ring structure through interactions with other LSM subunits, facilitating binding to the oligoadenylated tails of mRNAs. Beyond RNA turnover, LSM6 is implicated in stress granule formation during cellular stress responses. Dysregulation of LSM6 has been associated with pathological conditions, including cancer and neurodegenerative diseases, likely due to altered RNA stability or misregulated gene expression. Recombinant human LSM6 proteins are typically produced in bacterial or mammalian expression systems for functional studies, enabling researchers to explore its structural interactions, RNA-binding specificity, and role in cellular pathways. Such recombinant tools also aid in screening for molecules modulating LSM6 activity, offering potential therapeutic avenues. Ongoing research focuses on clarifying its regulatory mechanisms and validating its utility as a biomarker or drug target in diseases linked to RNA-processing defects.
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