| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | LRRC61 |
| Uniprot No | Q9BV99 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-259aa |
| 活性数据 | MDPPAEKPGEAGGLQITPQLLKSRTGEFSLESILLLKLRGLGLADLGCLGECLGLEWLDLSGNALTHLGPLASLRQLAVLNVSNNRLTGLEPLATCENLQSLNAAGNLLATPGQLQCLAGLPCLEYLRLRDPLARLSNPLCANPSYWAAVRELLPGLKVIDGERVIGRGSEFYQLCRDLDSSLRPSSSPGPRATEAQPWVEPGYWESWPSRSSSILEEACRQFQDTLQECWDLDRQASDSLAQAEQVLSSAGPTSSFVF |
| 分子量 | 54.4 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人LRRC61蛋白的3篇代表性文献摘要(基于现有领域知识推测，实际文献可能需要进一步检索验证)：
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1. **文献名称**: *Structural characterization of human LRRC61 and its role in microtubule dynamics*
**作者**: Zhang Y, et al.
**摘要**: 本研究通过大肠杆菌表达系统成功制备了重组人LRRC61蛋白，并利用X射线晶体学解析其结构，揭示其N端富含亮氨酸重复序列(LRR)及C端卷曲螺旋结构域。功能实验表明，LRRC61通过结合微管蛋白调控微管网络稳定性，影响细胞分裂进程。
2. **文献名称**: *LRRC61 interacts with IFT complexes and regulates ciliogenesis in human cells*
**作者**: Gupta S, et al.
**摘要**: 研究者通过哺乳动物细胞表达重组人LRRC61蛋白，发现其与纤毛内运输(IFT)蛋白复合物互作。敲低LRRC61导致纤毛组装缺陷，提示其在纤毛形成中的调节作用，可能通过影响微管相关蛋白的运输实现。
3. **文献名称**: *Proteomic screening identifies LRRC61 as a novel binding partner of viral envelope proteins*
**作者**: Lee H, et al.
**摘要**: 利用重组LRRC61蛋白进行蛋白质互作筛选，发现其与多种病毒的囊膜蛋白(如流感病毒HA)存在结合。该研究推测LRRC61可能在宿主细胞抗病毒反应中发挥作用，或参与病毒侵染的早期阶段。
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**注意**：以上为模拟文献摘要，实际文献可能需要通过PubMed、Google Scholar等平台以关键词“LRRC61”、“recombinant LRRC61”或“LRRC61 function”检索核实。若研究较少，可扩展至LRRC蛋白家族综述文献。
Recombinant human LRRC61 protein is a genetically engineered form of the leucine-rich repeat-containing protein 61 (LRRC61), encoded by the *LRRC61* gene in humans. Belonging to the leucine-rich repeat (LRR) superfamily, LRRC61 features characteristic LRR domains—structural motifs involved in protein-protein interactions, signaling, and molecular scaffolding. While the precise biological function of native LRRC61 remains partially characterized, it is hypothesized to participate in cellular processes such as immune regulation, intracellular trafficking, or transcriptional modulation due to its structural motifs and inferred interactions.
The recombinant version is typically produced in heterologous expression systems (e.g., *E. coli*, mammalian cells) to enable functional studies. Its production allows researchers to explore its role in pathways linked to disease, including cancer or inflammatory conditions, where dysregulated LRR proteins are often implicated. Structural studies of recombinant LRRC61 may also elucidate its interaction partners or conformational dynamics. Current research focuses on mapping its tissue-specific expression, post-translational modifications, and potential involvement in signaling cascades, such as NF-κB or MAPK pathways. As a recombinant tool, it serves as a reagent for antibody development, protein interaction assays, or mechanistic studies aiming to uncover its physiological relevance in health and disease.
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