| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | LRRC28 |
| Uniprot No | Q86X40 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-367aa |
| 活性数据 | MASELCKTIS VARLEKHKNL FLNYRNLHHF PLELLKDEGL QYLERLYMKR NSLTSLPENL AQKLPNLVEL YLHSNNIVVV PEAIGSLVKL QCLDLSDNAL EIVCPEIGRL RALRHLRLAN NQLQFLPPEV GDLKELQTLD ISTNRLLTLP ERLHMCLSLQ YLTVDRNRLW YVPRHLCQLP SLNELSMAGN RLAFLPLDLG RSRELQYVYV DNNIHLKGLP SYLYNKVIGC SGCGAPIQVS EVKLLSFSSG QRTVFLPAEV KAIGTEHDHV LPLQELAMRG LYHTYHSLLK DLNFLSPISL PRSLLELLHC PLGHCHRCSE PMFTIVYPKL FPLRETPMAG LHQWKTTVSF VAYCCSTQCL QTFDLLS |
| 分子量 | 41.9 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人LRRC28蛋白的参考文献示例(内容基于研究领域常见方向合理整合，非真实文献)：
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1. **"Expression and purification of recombinant human LRRC28 in mammalian cells"**
*作者：Zhang Y. et al.*
**摘要**：本研究构建了LRRC28蛋白的哺乳动物细胞表达系统，优化了纯化工艺并验证了其结构完整性，为后续功能研究提供高纯度样本。
2. **"LRRC28 modulates TGF-β signaling through interaction with receptor complexes"**
*作者：Kim S. et al.*
**摘要**：通过体外重组LRRC28蛋白实验，揭示了其通过结合TGF-β受体调控信号通路的机制，暗示其在细胞分化与纤维化中的潜在作用。
3. **"Structural analysis of LRRC28 reveals leucine-rich repeat domain-mediated protein interactions"**
*作者：Wang X. et al.*
**摘要**：利用X射线晶体学解析重组人LRRC28的结构，发现其LRR结构域参与形成蛋白互作界面，为研究其在先天免疫中的功能提供结构基础。
4. **"LRRC28 as a potential biomarker in renal cell carcinoma: Insights from recombinant protein-based assays"**
*作者：Lee J. & Chen H.*
**摘要**：通过重组LRRC28建立的ELISA检测平台，发现其在肾癌细胞中的异常表达，提示其作为疾病分子标志物的可能性。
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**说明**：以上文献为领域合理性示例，实际研究中需通过PubMed等数据库检索真实文献。若需具体文章，建议使用关键词 **"LRRC28" AND "recombinant"** 进一步筛选。
The leucine-rich repeat-containing protein 28 (LRRC28) is a member of the LRRC protein family, characterized by conserved leucine-rich repeat (LRR) domains that mediate protein-protein interactions and cellular signaling. Human LRRC28 is encoded by the *LRRC28* gene and is implicated in regulating signaling pathways associated with cellular proliferation, differentiation, and tissue homeostasis. Structurally, LRRC28 contains multiple LRR motifs, which are critical for its role in scaffolding or modulating interactions with other proteins, such as receptors or kinases. While its exact physiological functions remain under investigation, studies suggest LRRC28 may influence pathways like Wnt/β-catenin or TGF-β, potentially impacting cancer progression or developmental disorders.
Recombinant human LRRC28 protein is produced using biotechnological systems (e.g., bacterial, insect, or mammalian expression platforms) to enable functional studies. Its recombinant form allows researchers to explore its biochemical properties, interaction networks, and therapeutic potential in vitro or in vivo. Applications include elucidating mechanisms in cellular signaling, validating drug targets, or understanding its role in diseases like fibrosis or malignancies. Despite limited characterization compared to other LRRC members, its structural features and expression patterns in tissues such as the brain, kidneys, and heart highlight its biological relevance. Further research on recombinant LRRC28 could advance insights into its molecular functions and translational applications.
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