| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | LRRC18 |
| Uniprot No | Q8N456 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-261aa |
| 活性数据 | MVKGEKGPKGKKITLKVARNCIKITFDGKKRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVSTTLGALKELHEVGLHDNLLNNIPVSISKLPKLKKLNIKRNPFPKPGESEIFIDSIRRLENLYVVEEKDLCAACLRKCQNARDNLNRIKNMATTTPRKTIFPNLISPNSMAKDSWEDWRIRLTSS |
| 分子量 | 56.1 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人LRRC18蛋白的参考文献示例(注：由于LRRC18研究较为前沿，实际文献可能较少，以下为模拟内容)：
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1. **"Expression and Functional Characterization of Recombinant Human LRRC18 in Immune Regulation"**
*Authors: Zhang Y, Wang L, Li H*
摘要：本研究成功在大肠杆菌中表达并纯化了重组人LRRC18蛋白，通过免疫共沉淀和体外实验发现，LRRC18可与Toll样受体(TLR4)直接相互作用，抑制炎症信号通路，提示其在先天免疫调控中的潜在作用。
2. **"Structural Insights into LRRC18 and Its Role in Cancer Cell Migration"**
*Authors: Chen X, Tanaka K, Liu R*
摘要：通过冷冻电镜解析了LRRC18蛋白的三维结构，揭示了其富含亮氨酸重复序列的结构特征。体外实验表明，重组LRRC18可增强乳腺癌细胞的迁移能力，提示其可能作为肿瘤治疗的潜在靶点。
3. **"LRRC18 Modulates Neuronal Axon Guidance via Semaphorin Signaling"**
*Authors: Kim S, Park J, Lee M*
摘要：研究利用重组人LRRC18蛋白进行体外神经元培养实验，发现LRRC18通过竞争性结合Semaphorin 3A受体(Neuropilin-1)，影响轴突导向，为神经发育机制提供了新见解。
4. **"High-Throughput Screening Identifies LRRC18 as a Novel Regulator of Autophagy"**
*Authors: Müller F, García-Sáez AJ, Ramos A*
摘要：通过基因筛选和重组蛋白功能验证，发现LRRC18可与自噬相关蛋白Beclin-1结合，抑制自噬体形成，为研究自ophagy与疾病的关联提供了新方向。
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**说明**：
以上文献为模拟示例，实际研究中LRRC18的功能和参考文献可能有限。建议通过PubMed或Web of Science以“LRRC18 protein”、“recombinant LRRC18”等关键词检索最新文献，或关注相关信号通路(如免疫、神经或肿瘤)的延伸研究。
**Background of Recombinant Human LRRC18 Protein**
Leucine-rich repeat-containing protein 18 (LRRC18) is a member of the leucine-rich repeat (LRR) superfamily, characterized by repeats of 20-30 amino acids rich in leucine residues. These proteins are typically involved in protein-protein interactions, cellular signaling, and immune regulation. LRRC18. though less studied compared to other LRR proteins, is thought to play roles in immune system modulation and cellular adhesion processes. Its exact physiological functions and mechanisms, however, remain poorly understood due to limited research.
Recombinant human LRRC18 protein is engineered using heterologous expression systems (e.g., *E. coli*, mammalian cells) to enable functional and structural studies. This protein is critical for investigating its interactions with ligands, receptors, or pathways, particularly in contexts like inflammation, autoimmune diseases, or cancer. The recombinant form allows researchers to explore its potential as a biomarker or therapeutic target.
Recent studies suggest LRRC18 may influence immune cell behavior or tissue homeostasis, but confirmatory evidence is lacking. Its expression patterns in specific tissues, such as the thymus or immune-related organs, further hint at its immunological relevance. By producing recombinant LRRC18. scientists aim to unravel its molecular interactions, post-translational modifications, and contributions to disease pathology, bridging gaps in understanding its biological significance.
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