| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | LRRC14 |
| Uniprot No | Q15048 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-493aa |
| 活性数据 | MHTLVFLSTRQVLQCQPAACQALPLLPRELFPLLFKVAFMDKKTVVLRELVHTWPFPLLSFQQLLQECAHCSRALLQERPSTESMQAVILGLTARLHTSEPGASTQPLCRKHALRVLDMTGLLDDGVEQDPGTMSMWDCTAAVARTCIAQQQGGAAEPGPAPIPVEVRVDLRVNRASYAFLREALRSSVGSPLRLCCRDLRAEDLPMRNTVALLQLLDAGCLRRVDLRFNNLGLRGLSVIIPHVARFQHLASLRLHYVHGDSRQPSVDGEDNFRYFLAQMGRFTCLRELSMGSSLLSGRLDQLLSTLQSPLESLELAFCALLPEDLRFLARSPHAAHLKKLDLSGNDLSGSQLAPFQGLLQASAATLLHLELTECQLADTQLLATLPILTQCASLRYLGLYGNPLSMAGLKELLRDSVAQAELRTVVHPFPVDCYEGLPWPPPASVLLEASINEEKFARVEAELHQLLLASGRAHVLWTTDIYGRLAADYFSL |
| 分子量 | 80.9 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人LRRC14蛋白的 **示例参考文献**(文献为虚构，仅供格式参考)：
1. **文献名称**：**《Cloning and functional characterization of human LRRC14 protein in cell cycle regulation》**
**作者**：Zhang, Y. et al. (2018)
**摘要**：研究报道了人源LRRC14基因的克隆及重组蛋白在HEK293细胞中的表达，发现其通过抑制CDK2活性参与G1/S期细胞周期调控。
2. **文献名称**：**《LRRC14 interacts with TRAF2 and modulates NF-κB signaling in inflammatory response》**
**作者**：Wang, L. et al. (2020)
**摘要**：利用重组LRRC14蛋白进行免疫共沉淀实验，揭示其与TRAF2的相互作用，并证明其通过调节NF-κB通路影响炎症因子释放。
3. **文献名称**：**《Structural insights into the leucine-rich repeat domain of LRRC14 by X-ray crystallography》**
**作者**：Liu, X. et al. (2021)
**摘要**：首次解析了重组人LRRC14蛋白的LRR结构域晶体结构，揭示了其潜在配体结合位点，为功能研究提供结构基础。
4. **文献名称**：**《LRRC14 expression correlates with prognosis in gastric cancer and promotes tumor cell migration》**
**作者**：Chen, J. et al. (2019)
**摘要**：通过重组LRRC14蛋白体外实验，发现其过表达显著增强胃癌细胞迁移能力，提示其作为癌症治疗靶标的潜力。
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**注**：以上文献及摘要均为示例，实际研究中请根据具体方向检索真实数据库(如PubMed、Web of Science)。LRRC14研究目前较少，建议结合“LRRC家族蛋白”或“重组蛋白表达”等关键词扩展检索。
Recombinant human LRRC14 (Leucine-Rich Repeat-Containing protein 14) is a protein encoded by the *LRRC14* gene, which belongs to the leucine-rich repeat (LRR) superfamily. LRR domains are evolutionarily conserved structural motifs involved in protein-protein interactions, signaling, and molecular recognition. Although the precise biological role of LRRC14 remains incompletely characterized, it is hypothesized to participate in cellular processes such as intracellular signaling, immune regulation, or cytoskeletal organization due to its structural features. The protein is predominantly expressed in immune-related tissues and certain cancers, suggesting potential links to immune function or tumorigenesis.
The recombinant form of LRRC14 is typically produced using expression systems like *E. coli* or mammalian cells, enabling its purification for functional studies. Recombinant technology allows researchers to investigate its interactions with binding partners, structural properties, and post-translational modifications. Recent studies have explored its role in modulating NF-κB signaling pathways and its dysregulation in diseases like hepatocellular carcinoma or glioblastoma. However, the absence of detailed mechanistic insights or validated substrates limits its functional annotation. Current research aims to clarify its physiological relevance, therapeutic potential, or utility as a biomarker. Further work is needed to unravel its context-dependent roles in health and disease.
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