| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | LOC57146 |
| Uniprot No | 0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-161aa |
| 活性数据 | MAKEEPQSISRDLQELQKKLSLLIDSFQNNSKVVAFMKSPVGQYLDSHPFLAFTLLVFIVMSAVPVGFFLLIVVLTTLAALLGVIILEGLVISVGGFSLLCILCGLGFVSLAMSGMMIASYVVVSSLISCWFSPRPLTQQNTSCDFLPAMKSADFEGLYQE |
| 分子量 | 43.9 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
由于"LOC57146"是NCBI临时命名且可能已被更新，以下为基于假设的模拟参考文献示例(实际文献可能不存在或使用新基因名)。建议核实该基因当前命名(如通过NCBI Gene数据库)：
1. **文献名称**: *Cloning and expression analysis of recombinant human LOC57146 in E. coli*
**作者**: Zhang L. et al.
**摘要**: 报道了LOC57146基因的克隆、原核表达及纯化，证实其编码蛋白具有ATP结合活性，可能在细胞能量代谢中发挥作用。
2. **文献名称**: *Functional characterization of LOC57146 as a novel tumor suppressor in lung cancer*
**作者**: Tanaka K. et al.
**摘要**: 通过重组LOC57146蛋白体外实验，发现其抑制肺癌细胞增殖，并揭示其通过调控p53信号通路诱导凋亡。
3. **文献名称**: *Structural insights into LOC57146: A crystallographic study*
**作者**: Smith R. et al.
**摘要**: 解析了重组LOC57146蛋白的晶体结构，发现其与激酶家族结构相似，提示潜在催化功能，为药物靶点开发提供基础。
**注意**: 以上为模拟内容，实际研究中"LOC57146"可能已更名为其他基因符号(如已注释为特定功能基因)。建议查询最新数据库确认信息。
**Background of Recombinant Human LOC57146 Protein**
The human *LOC57146* gene, also known by alternative identifiers or aliases depending on functional annotations, encodes a protein whose precise biological role remains under investigation. This gene is located on chromosome X (Xq22.3) and is classified as a member of the FAM9 protein family, which shares homology with cancer/testis antigen proteins. While its exact physiological function is not fully elucidated, studies suggest potential involvement in cellular processes such as gametogenesis, cell adhesion, or transcriptional regulation, inferred from structural motifs and expression patterns.
Recombinant human LOC57146 protein is artificially produced using expression systems like *E. coli* or mammalian cells, enabling functional and structural studies. Its production facilitates research into its interactions, post-translational modifications, and potential roles in diseases. For instance, FAM9 family proteins are implicated in germ cell development and certain cancers, suggesting LOC57146 might contribute to similar pathways. Current applications include antibody development, protein-protein interaction assays, and exploratory studies in cancer biology or reproductive health.
Despite progress, gaps remain in understanding its *in vivo* significance, driving ongoing research to clarify its mechanisms and therapeutic potential in disorders linked to X-chromosome anomalies or cell differentiation defects.
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