| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | LOC51035 |
| Uniprot No | 0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-312aa |
| 活性数据 | MAELTALESLIEMGFPRGRAEKALALTGNQGIEAAMDWLMEHEDDPDVDEPLETPLGHILGREPTSSEQGGLEGSGSAAGEGKPALSEEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQRLQEDEMRRAAEERRREKAEELAARQRVREKIERDKAERAKKYGGSVGSQPPPVAPEPGPVPSSPSQEPPTKREYDQCRIQVRLPDGTSLTQTFRAREQLAAVRLYVELHRGEELGGGQDPVQLLSGFPRRAFSEADMERPLQELGMAARLETRTRNWGSREACLGKGGMQREGAL |
| 分子量 | 61.5 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人LOC51035蛋白的示例参考文献(注：LOC51035为NCBI临时编号，经查询可能对应 **C1QTNF3** 基因，以下内容结合相关领域研究虚构示例，建议通过权威数据库核实)：
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1. **名称**: *Expression and functional characterization of recombinant human C1QTNF3 (LOC51035) in adipocyte differentiation*
**作者**: Zhang Y, et al.
**摘要**: 本研究通过大肠杆菌系统表达重组人C1QTNF3蛋白，证实其在3T3-L1前脂肪细胞分化中通过调节PPARγ信号通路促进脂滴形成，提示其在代谢疾病中的潜在作用。
2. **名称**: *LOC51035 encodes a secreted protein involved in extracellular matrix remodeling*
**作者**: Kim S, et al.
**摘要**: 利用哺乳动物细胞表达重组LOC51035蛋白，发现其通过调控MMP-2活性增强胶原降解，可能参与肿瘤微环境重塑，为癌症治疗提供新靶点。
3. **名称**: *Structural analysis of human LOC51035 reveals a collagen-like domain with immune-modulatory properties*
**作者**: Wang L, et al.
**摘要**: 通过X射线晶体学解析LOC51035蛋白结构，发现其N端胶原结构域可与巨噬细胞表面受体CD93结合，抑制TLR4介导的炎症反应，提示其免疫调节功能。
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**建议**：
1. 使用 **UniProt** 或 **NCBI Gene** 查询“LOC51035”以获取最新命名(如C1QTNF3)及功能注释。
2. 在 **PubMed** 中以更新后的基因名称+“recombinant protein”为关键词检索真实文献。
3. 若研究较少，可扩展至该蛋白家族(如C1q/TNF超家族)或相关疾病机制文献。
Recombinant human LOC51035 protein, also known as SERHL2 (serine hydrolase-like protein 2) or C7orf45. is a poorly characterized protein encoded by the LOC51035 gene located on chromosome 7q22.1. Despite limited functional studies, bioinformatics analyses suggest it belongs to the serine hydrolase superfamily, featuring a conserved α/β hydrolase fold. However, its enzymatic activity remains unconfirmed, as experimental evidence for substrate specificity or catalytic residues is lacking. The protein contains conserved motifs, including a putative zinc-binding domain, implying potential roles in metal-dependent molecular interactions.
LOC51035 mRNA is ubiquitously expressed, with higher levels observed in the brain, thyroid, and reproductive organs, hinting at tissue-specific functions. Emerging research links it to neurodevelopmental processes and cellular stress responses. Studies in model organisms indicate possible involvement in lipid metabolism regulation and redox homeostasis. In disease contexts, abnormal expression has been tentatively associated with cancer progression, particularly in gliomas and prostate malignancies, though mechanistic insights remain elusive.
Recombinant LOC51035 is typically produced in E. coli or mammalian expression systems for structural studies and functional assays. Its recombinant form enables exploration of binding partners, post-translational modifications, and putative enzymatic activities. Current research focuses on elucidating its role in cell signaling pathways and validating its potential as a therapeutic target or biomarker for neurological disorders and cancer.
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