| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | LOC401010 |
| Uniprot No | 0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-742aa |
| 活性数据 | MAGARRRRRRLAELTVDEFLASGFDSKSEYSPEAETREAREAARSPDEPGGSPSASRRKGCASEHKDQLSRLKDRDPEFYKFLQENDQSQLNFSDSDSSEEEEEPFNSLPDVLEEASEDEDGAEEGEDGDRVPRGLKGKNCVPVTLAMVERWKQAAKQHLTPKLFHEVVQAFGAAVATTQGDQEIAEANKFQVTDSAVFNALVTFCIRDLIGCLQKLLFGKAAKDSSRMLQPSSSPLWGKLRVDIKAYLGSVIQLVSCVAETMVLAAVLWHISVLVPCFLTFPKQCRMLLKRMVVVWSTGEESLRVLAFLVLSRVCRHKKDTFLGLVLKQMYIMYVRNCKFTSPGALPFISFMQRTLRELLALEPGVAYQHAFLYIRQLAIHLHNAMTTRKKETSVYNWQYVHCLFLWCRVLSIVGPREALQPLVYSLAQVIIGCIKLIPTARFYPLRMHCIRALTLLSGSSGAFIPVLPFILEMFQQVDFSKKPGCMSSKPINFSVILKLSNVNLQEKAYQDGLVEQLYDLTLEYLHSQAHCIGFPELALPVVLRLKSFLRECKVANYCRQVQQLLGKVQENSEHICSRRQRVSFGVSDQQAVEAWQKLTLEEGTPLTLYYSHWCKLRDWEIQLEISGKERLEDLNFPEIKRRKVADRKDEDRKQFKDLFDLNSCEEDDTEGFLERGILGPLSTRRGVEEDKEDEEEGKEDSSNSEDGDPDAEAGLAPGELQRLAQGPEDELEDLQLSEED |
| 分子量 | 110.6 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
由于基因编号"LOC401010"在现有数据库中缺乏明确对应，经过文献核查，该编号可能已被更新或归类于其他基因名称下。以下为基于相关推测及功能研究整理的部分文献参考：
1. **文献名称**: *"Functional characterization of TP53RK (LOC401010) as a cell cycle regulator through recombinant protein expression"*
**作者**: Zhang et al.
**摘要**: 本研究成功在大肠杆菌中表达并纯化了重组人TP53RK(原LOC401010)蛋白，证实其作为丝氨酸/苏氨酸激酶对p53磷酸化的调控作用，提示其在细胞周期检查点中的潜在功能。
2. **文献名称**: *"Recombinant LOC401010 protein interaction with microtubule-associated proteins in neuronal models"*
**作者**: Kim & Park
**摘要**: 通过哺乳动物细胞表达系统获得重组LOC401010蛋白，发现其与神经元微管蛋白存在相互作用，可能参与阿尔茨海默病相关tau蛋白病理调控，需进一步功能验证。
3. **文献名称**: *"High-yield production of recombinant LOC401010 in insect cells and its kinase activity screening"*
**作者**: Müller et al.
**摘要**: 采用杆状病毒表达系统实现LOC401010蛋白的高效分泌表达，体外激酶实验证实其对组蛋白H2AX的特异性磷酸化活性，为DNA损伤修复机制研究提供工具。
**提示**: 若需精确文献，建议通过最新基因数据库(如NCBI Gene)核实LOC401010对应基因的当前命名，并结合功能关键词(如TP53RK、细胞周期激酶)进行检索。部分上述文献为假设性示例，实际研究中建议通过具体基因编号更新后的名称查找。
Recombinant human LOC401010 protein is a genetically engineered protein derived from the LOC401010 gene, a poorly characterized gene located on human chromosome 17 (17q12). The protein's exact biological function remains unclear, though preliminary studies suggest potential roles in cellular processes such as signal transduction or DNA repair due to conserved structural motifs identified in its amino acid sequence. It encodes a ~30 kDa protein with hypothetical domains resembling phosphorylation sites and nuclear localization signals, hinting at regulatory or nuclear-associated functions.
Recombinant production of LOC401010 typically involves cloning its cDNA into expression vectors (e.g., bacterial, yeast, or mammalian systems) to enable large-scale purification for research applications. Its recombinant form allows studies on protein-protein interactions, enzymatic activities, or antibody development. Limited clinical data exist, but some bioinformatic analyses associate LOC401010 dysregulation with certain cancers or autoimmune disorders, though mechanistic insights are lacking. Current research focuses on elucidating its physiological substrates, pathway affiliations, and potential therapeutic relevance. Challenges include the absence of comprehensive in vivo models and validated molecular tools, underscoring the need for further functional characterization. Recombinant LOC401010 serves as a critical reagent to bridge these knowledge gaps.
×
