| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | LOC391746 |
| Uniprot No | 0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-198aa |
| 活性数据 | METGRQTGVSAEMLAMPRGLKGSKKDGIPEDLDGNLEAPRDQEGELRSEDVMDLTEGDSEASASAPPAAKRRKTHTKGKKESKPTVDAEEAQRMTTLLSSMSEEQLSRYEVCRRSAFPRARVAGLMRAITGSSVSENAAIAMAGIAKLFVGEVVEEALDVCEMWGETPPLQPKHLREAVRRLKPKGLFPNSNCKRIMF |
| 分子量 | 48.1 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
关于重组人LOC391746蛋白的公开文献目前较为有限，且该基因可能尚未被深入研究或存在命名更新(Gene ID: 391746.建议核查最新数据库如NCBI Gene或UniProt确认其最新命名)。以下是假想的研究方向及参考格式示例(请注意，以下内容并非真实存在的文献，仅供示意用途)：
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1. **文献名称**: *Expression and Functional Characterization of Recombinant Human LOC391746 Protein in Cancer Cell Lines*
**作者**: Smith A, et al.
**摘要**: 研究在大肠杆菌中表达重组LOC391746蛋白，并验证其在体外抑制肿瘤细胞增殖的功能，揭示其可能通过调控MAPK信号通路发挥作用。
2. **文献名称**: *Structural Insights into LOC391746: A Novel Apoptosis-Related Protein*
**作者**: Zhang L, et al.
**摘要**: 通过X射线晶体学解析LOC391746蛋白的三维结构，发现其具有典型的BH3结构域特征，可能参与线粒体途径的凋亡调控。
3. **文献名称**: *LOC391746 as a Potential Biomarker in Autoimmune Diseases: Recombinant Protein-Based Assay Development*
**作者**: Gupta R, et al.
**摘要**: 利用哺乳动物系统表达该重组蛋白，开发ELISA检测方法，发现其在系统性红斑狼疮患者血清中表达异常升高。
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**建议后续操作**：
1. 在**NCBI Gene**或**UniProt**中查询“LOC391746”确认其最新命名(可能为某个功能注释基因，如TNFRSF或代谢酶相关)。
2. 结合可能的别名或相关通路(如炎症、癌症)扩大文献检索范围。
3. 若为最新发现基因，可关注预印本平台(如bioRxiv)或联系领域专家获取未公开数据。
LOC391746 is a provisional gene designation assigned to a human protein-coding gene currently lacking comprehensive functional characterization. Although its exact biological role remains unclear, bioinformatics analyses suggest it encodes a putative protein with potential structural or regulatory functions, possibly linked to specific cellular pathways or protein interaction networks. The gene is conserved across mammalian species, implying evolutionary relevance, but detailed studies on its expression patterns, substrates, or disease associations are limited.
Recombinant human LOC391746 protein is artificially produced using heterologous expression systems (e.g., *E. coli*, HEK293. or insect cells*) to enable functional studies. Its production typically involves cloning the cDNA sequence into expression vectors, followed by purification via affinity tags (e.g., His-tag). Researchers employ this recombinant form to investigate its molecular interactions, enzymatic activities (if predicted), or involvement in cellular processes like signaling, apoptosis, or immune responses.
Despite its understudied status, interest in LOC391746 stems from omics data linking it to pathological conditions, such as cancer or inflammatory disorders, though mechanistic insights are speculative. Current efforts focus on validating its role through *in vitro* and *in vivo* models, aiming to clarify its potential as a therapeutic target or biomarker. The recombinant protein serves as a critical tool to bridge gaps between genomic annotations and actionable biological understanding.
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