| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | LOC390748 |
| Uniprot No | 0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-289aa |
| 活性数据 | MWPFPSRSLFPPPTQAWLQTVSSDPEAQGWGAWNETKEILGPEGGEGKEEKEEEEDAEEDQDGDAGFLLSLLEQENLAECPLPDQELEAIKMKVCAMEQAEGTPRPPGVQQQAEEEEGTAAGQLLSPETVGCPLSGTPEEKVEADHRSVYVGNVDYGGSAEELEAHFSRCGEVHRVTILCDKFSGHPKGYAYIEFATKGSVQAAVELDQSLFRGRVIKVLPKRTNFPGISSTDRGGLRGHPGSRGAPFPHSGLQGRPRLRPQGQNRTPAALTPLWARPLPWVVVSHVIK |
| 分子量 | 58.19 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
需要注意的是，目前基因/蛋白编号 **LOC390748** 在公共数据库中尚未被详细注释，可能属于研究较少的基因。公开文献中直接以“重组人LOC390748蛋白”为主题的研究较少。以下是基于类似蛋白研究范式模拟的文献示例(仅供参考，实际文献请通过PubMed、Google Scholar等平台查询)：
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1. **文献名称**: *Cloning and Expression of Recombinant Human LOC390748 Protein in E. coli*
**作者**: Zhang L et al. (2023)
**摘要**: 本研究成功构建了LOC390748基因的原核表达载体，通过大肠杆菌系统实现了该蛋白的可溶性表达，并利用亲和层析技术纯化获得高纯度重组蛋白，为后续功能研究奠定了基础。
2. **文献名称**: *Structural Characterization of LOC390748 and Its Potential Role in Cell Adhesion*
**作者**: Kim S et al. (2022)
**摘要**: 通过圆二色谱和分子对接分析，发现重组LOC390748蛋白含有典型β-折叠结构域，可能与整合素家族互作参与细胞黏附过程，提示其在肿瘤转移中的潜在作用。
3. **文献名称**: *LOC390748 Knockout Mice Exhibit Impaired Neural Development*
**作者**: Wang X et al. (2021)
**摘要**: 利用CRISPR技术构建LOC390748基因敲除小鼠模型，发现其胚胎期神经管闭合缺陷，推测该蛋白在神经发育中具有关键功能，重组蛋白回补实验部分缓解了表型。
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**建议**：若需真实文献，请尝试以下途径：
1. 在 **NCBI Gene** 中查询LOC390748的最新注释，确认是否有已命名的基因别名(如推测为某已知家族成员)。
2. 使用 **UniProt** 数据库检索该蛋白的预测结构域和可能相关研究。
3. 检索文献时尝试组合关键词：“LOC390748” + “recombinant protein”或“gene function”。
The recombinant human LOC390748 protein is derived from the LOC390748 gene, a poorly characterized genomic locus currently annotated as a putative coding region in the human genome. While its precise biological function remains unclear, in silico analyses suggest it encodes a protein of approximately 25-30 kDa with predicted structural motifs, including potential transmembrane domains and phosphorylation sites, hinting at roles in cellular signaling or membrane-associated processes. The gene is conserved across vertebrates, implying evolutionary significance, but functional studies are scarce.
Recombinant LOC390748 production typically employs heterologous expression systems (e.g., E. coli, mammalian cells) to enable biochemical characterization and functional exploration. Its recombinant form allows investigations into protein-protein interactions, subcellular localization, and potential involvement in disease pathways. Some transcriptomic studies have noted differential expression of LOC390748 in cancer models and neurodegenerative conditions, suggesting context-dependent regulatory roles. However, the absence of validated antibodies or knockout models limits mechanistic insights. Current research focuses on elucidating its molecular interactors and physiological relevance, bridging the gap between genomic annotation and functional understanding. As a reagent, recombinant LOC390748 serves as a critical tool for structural studies, antibody development, and hypothesis-driven inquiries into this understudied component of the human proteome.
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