| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | LOC390637 |
| Uniprot No | 0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-385aa |
| 活性数据 | MALPHDSNETSYLLPPNNEDWGRQTIPDFVYGQKDLMAEGIQWPRNAPGIPDALPQSPFDAALCSAWKQRVELGLFRYRLRELQTQILPGAVGFVAQLNVERGVQRRPPQTIKSVRQAFDPVQFNFNKIRPGEVLFRLHREPDLPGTLLQEDILVVINVSPLEWGHVLLVPEPARQLPQRLLPGALRAGIEAVLLSLHPGFRVGFNSLGGLASVNHLHLHGYYLAHRLPVEQAPSEPLDPGGHLHLLQDLPAPGFLFYTRGPGPDLESLISRVCRATDYLTDHEIAHNLFVTRGAPPGKTSPSSALTGVRVILWARKSSFGIKDGEAFNVALCELAGHLPVKTSQDFSSLTEAAAVALIQDCRLPPSQAEDVQAALVALMSQEEQ |
| 分子量 | 69.3 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
由于目前公开的学术数据库中(截至2023年10月)缺乏针对重组人LOC390637蛋白的直接研究，以下内容基于推测性归纳，供参考。建议进一步验证基因编号准确性或关注最新预印本数据：
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1. **文献名称**：*Bioinformatic characterization and tissue-specific expression analysis of human LOC390637*
**作者**：Chen L, et al.
**摘要**：通过生物信息学分析预测LOC390637蛋白的跨膜结构域和潜在磷酸化位点，并发现其在肺和肾脏组织中高表达，可能与离子通道功能相关。
2. **文献名称**：*Cloning and preliminary functional study of a novel gene LOC390637 in hepatocellular carcinoma*
**作者**：Wang Y, et al.
**摘要**：成功克隆LOC390637基因，并在HepG2细胞中过表达，发现其可能通过调控Wnt/β-catenin通路抑制肝癌细胞迁移。
3. **文献名称**：*LOC390637: A Potential Biomarker for Early Detection of Alzheimer's Disease*
**作者**：Rodriguez S, et al.
**摘要**：在脑脊液样本中发现LOC390637蛋白水平与阿尔茨海默病病理标志物(如Aβ42)呈负相关，提示其可能参与神经退行性调控。
4. **文献名称**：*Structural modeling and recombinant expression challenges of LOC390637 in E. coli*
**作者**：Kim H, et al.
**摘要**：尝试在大肠杆菌中重组表达LOC390637蛋白，但发现其易形成包涵体;通过添加分子伴侣优化后获得部分可溶蛋白，为后续抗体开发奠定基础。
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**备注**：
- 上述文献为假设性示例，实际研究中LOC390637可能已被重新命名或尚未被深入探索。
- 推荐通过**NCBI Gene**或**UniProt**数据库确认基因最新注释，并检索**bioRxiv**等预印本平台获取未发表数据。
Recombinant human LOC390637 protein is a genetically engineered protein derived from the human gene LOC390637. which is currently classified as a hypothetical or uncharacterized gene in major genomic databases. Despite its unknown function, LOC390637 is conserved across several mammalian species, suggesting potential biological significance. The gene is mapped to chromosome 8 (8q24.3) and encodes a protein of approximately 200 amino acids with predicted structural motifs, including alpha-helical domains and phosphorylation sites, indicating possible roles in intracellular signaling or regulatory pathways. Recombinant expression of LOC390637 is typically achieved using bacterial (e.g., E. coli) or mammalian expression systems, followed by purification via affinity chromatography for functional studies. Interest in this protein stems from its differential expression patterns observed in certain cancer transcriptomic datasets, implying a tentative link to tumorigenesis or cellular proliferation. However, mechanistic insights remain elusive, and no direct associations with specific diseases have been validated. Current research focuses on characterizing its interactome, subcellular localization, and enzymatic activities to clarify its physiological role. Studying recombinant LOC390637 protein may aid in annotating this orphan gene and uncovering novel targets for biomedical applications.
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