| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | LOC388524 |
| Uniprot No | 0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-295aa |
| 活性数据 | MSGALDVLQMKEEDVLKFLAAGTHLGGTNLDFQMEQYIYKRKSDGIYIINLKRTWEKLLLAARAIVAIENPADVSVISSRNTGQRAVLKFAAATGATPIAGRFTPGTFTNQIQAAFWEPRLLVVTDPRADHQPLTEASYVNLPTIALCNTDSPLRYVDIAIPCNNKGAHSVGLMWWMLAREVLRMRGTISREHPWEVMPDLYFYRDPEEIEKEEQAAAEKAVTKEEFQGEWTAPAPEFTATQPEVADWSEGVQVPSVPIQQFPTEDWSAQPAMEDWSAAPTAQATEWVGATTDWS |
| 分子量 | 59.3 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是假设性的示例参考文献(请注意：LOC388524相关研究有限，实际文献可能较少，建议通过基因数据库如NCBI或专业期刊进一步检索)：
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1. **文献名称**：LOC388524 encodes a novel retinal pigment epithelium protein associated with age-related macular degeneration
**作者**：Smith J, et al.
**摘要**：本研究首次鉴定了LOC388524基因编码的蛋白在视网膜色素上皮细胞中的表达，发现其参与补体调控通路，可能与年龄相关性黄斑变性(AMD)的病理机制相关。通过重组蛋白实验证实其具有抗氧化应激功能。
2. **文献名称**：Structural and functional characterization of recombinant human LOC388524 protein
**作者**：Chen L, et al.
**摘要**：报道了重组人LOC388524蛋白在大肠杆菌中的高效表达与纯化方法，通过X射线晶体学解析其三维结构，揭示了其可能的蛋白相互作用界面，为靶向药物开发提供基础。
3. **文献名称**：LOC388524 modulates TGF-β signaling in pulmonary fibrosis
**作者**：Wang Y, et al.
**摘要**：发现LOC388524蛋白通过与TGF-β受体结合调控肺纤维化进程，动物实验表明重组LOC388524可减轻小鼠模型中的纤维化损伤，提示其作为治疗靶点的潜力。
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**建议补充检索**：
- 使用UniProt数据库查询"LOC388524"(对应UniProt ID：A6NIX2)获取最新注释
- 在PubMed中检索"LOC388524"或"A6NIX2"筛选实验性研究
- 关注相关疾病(如AMD、纤维化)的综述文献中是否提及该蛋白
Recombinant human LOC388524 protein is a product of the LOC388524 gene, which remains poorly characterized in current scientific literature. The gene is located on chromosome 10 (10q26.3) and encodes a hypothetical protein with unknown primary function. Bioinformatics analyses suggest it may possess structural motifs indicative of secreted or membrane-associated proteins, including potential signal peptides and transmembrane domains. Its restricted expression patterns in certain tissues (e.g., testes, brain) hint at tissue-specific roles, though no direct disease associations have been conclusively established. Limited studies propose possible involvement in cellular adhesion or receptor-ligand interactions, but these hypotheses require experimental validation.
Recombinant production of LOC388524 typically involves heterologous expression systems like E. coli or mammalian cell lines, followed by purification via affinity tags. The protein's recombinant form enables functional studies to investigate its biological activities, potential binding partners, and therapeutic relevance. While no commercial applications currently exist, interest persists due to its uncharacterized status in the human proteome and possible connections to developmental processes or pathological conditions. Research challenges include the lack of specific antibodies and standardized functional assays. Ongoing efforts focus on elucidating its 3D structure, interactome, and role in cellular pathways using recombinant protein tools, positioning LOC388524 as an intriguing target for exploratory biomedical research.
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