| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | LOC388272 |
| Uniprot No | Q6PH81 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-154aa |
| 活性数据 | MSATRAKKVKMATKSCPECDQQVPVACKSCPCGYIFISRKLLNAKHSEKSPPSTENKHEAKRRRTERVRREKINSTVNKDLENRKRSRSNSHSDHIRRGRGRPKSASAKKHEEEREKQEKEIDIYANLSDEKAFVFSVALAEINRKIINQRLIL |
| 分子量 | 44.2 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下提供的参考文献示例基于当前对LOC388272基因相关研究的合理推测，该基因位于10q26区域(与年龄相关性黄斑变性相关)，实际文献可能需要通过专业数据库进一步验证：
1. **文献名称**: *Characterization of recombinant human LOC388272 protein in retinal pigment epithelial cells*
**作者**: Smith, J. et al.
**摘要**: 研究成功表达了重组LOC388272蛋白，并发现其在体外可调控补体通路，提示其可能参与AMD的病理过程，为治疗靶点提供依据。
2. **文献名称**: *LOC388272 interacts with HTRA1: Implications for extracellular matrix remodeling*
**作者**: Zhang, L. et al.
**摘要**: 通过质谱分析发现LOC388272蛋白与HTRA1存在直接互作，可能通过调控细胞外基质降解影响AMD及纤维化疾病的发展。
3. **文献名称**: *Functional polymorphism of LOC388272 and its recombinant protein in inflammatory response*
**作者**: Kim, H. & Park, S.
**摘要**: 构建了LOC388272重组蛋白，证明其通过调节NF-κB信号通路抑制巨噬细胞炎症因子释放，提示抗炎治疗潜力。
4. **文献名称**: *Proteomic identification of LOC388272 as a mitochondrial-associated protein*
**作者**: Garcia, R. et al.
**摘要**: 重组蛋白标记实验显示LOC388272定位于线粒体，可能与氧化应激反应相关，或解释其在神经退行性疾病中的作用。
**注意**：上述文献为模拟示例，实际研究中LOC388272可能与相邻基因ARMS2/HTRA1存在共定位关系，建议通过PubMed或Google Scholar以“10q26 protein”、“ARMS2/HTRA1 locus”及“recombinant protein”等关键词检索最新文献。
**Background of Recombinant Human LOC388272 Protein**
The human *LOC388272* gene, currently identified by its provisional locus symbol, encodes a protein whose functional and structural characteristics remain under investigation. While detailed biological insights are limited, bioinformatic analyses suggest potential roles in cellular processes, possibly linked to membrane-associated functions or signal transduction pathways. The recombinant form of LOC388272 protein is artificially produced using expression systems (e.g., *E. coli*, mammalian cells) to enable large-scale studies.
Interest in recombinant LOC388272 arises from its hypothetical involvement in disease contexts, such as cancer or metabolic disorders, inferred from gene expression profiling or genetic association studies. Its recombinant production facilitates biochemical characterization, antibody development, and functional assays to clarify its interaction networks and mechanistic contributions.
Current research challenges include resolving its 3D structure, validating physiological substrates or binding partners, and defining its tissue-specific expression patterns. Further studies are required to establish its therapeutic potential or diagnostic relevance. As a poorly characterized protein, LOC388272 represents an emerging target in proteomics, underscoring the need for integrated omics approaches to unravel its role in human biology and pathology.
×
