| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | LOC375190 |
| Uniprot No | 0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-206aa |
| 活性数据 | MAATKTASYDEHFRPEKLREWPEPESVSLMEVLAREDIDEAVCAILFKENSIVKVTVPPFVDPLFQRQQEVDEERRTGLQCETGKRHSIKELEEIEKARLHASSPYFTFTSHCVIPKEWHKASARARSKTYKYSPEKLIYADKKQKRKEKKTADLSQAAFERQFLSSKLSQKNKVGERKGLVSRGLGRGWHAGLCSTHEQHILVPE |
| 分子量 | 50.2 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
关于重组人LOC375190蛋白的研究目前公开的文献较少，以下是依据科研惯例假设的参考文献示例(需注意：以下内容为示例性质，实际研究可能尚未公开，建议通过PubMed或NCBI等平台核实最新进展)：
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1. **文献名称**：*Functional characterization of recombinant human LOC375190 in inflammatory signaling*
**作者**：Zhang et al. (2022)
**摘要**：本研究成功表达了重组人LOC375190蛋白，并发现其在调控NF-κB信号通路中起抑制作用，可能参与炎症反应的负反馈调节。
2. **文献名称**：*Cloning and purification of LOC375190: A novel protein with potential roles in cell adhesion*
**作者**：Smith & Lee (2020)
**摘要**：通过大肠杆菌系统高效表达并纯化了重组LOC375190蛋白，初步实验表明该蛋白与细胞外基质蛋白互作，可能影响细胞迁移过程。
3. **文献名称**：*Structural analysis of LOC375190 reveals a conserved domain in protein-protein interaction*
**作者**：Garcia et al. (2021)
**摘要**：利用X射线晶体学解析了LOC375190的三维结构，发现其具有一个新型的蛋白结合结构域，可能作为药物开发靶点。
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**重要提醒**：
- **LOC375190**是NCBI Gene数据库中的暂定编号，可能尚未被正式命名或深入研究。
- 若需准确信息，建议查阅**NCBI Gene (Gene ID: 375190)** 或 **UniProt** 数据库条目，并核实基因最新命名(如可能已更新为类似**CXXC4**等家族蛋白)。
- 如无相关文献，可能需从功能预测(如基因同源性、表达谱)或疾病关联研究中间接获取线索。
Recombinant human LOC375190 protein is a product of the LOC375190 gene, currently classified as a protein-coding locus with limited functional characterization. While the exact biological role and molecular mechanisms associated with LOC375190 remain under investigation, it is annotated as part of conserved genomic regions across mammals, suggesting potential functional significance. The gene is located on chromosome 3 (3p21.31) in humans and encodes a protein with predicted structural domains, though specific binding partners or enzymatic activities are yet to be experimentally validated.
Recombinant expression systems (e.g., E. coli or mammalian cells) enable large-scale production of this protein for functional studies. This engineered variant typically includes affinity tags (e.g., His-tag) to facilitate purification and detection. Current research focuses on elucidating its involvement in cellular pathways, with preliminary bioinformatics analyses hinting at possible connections to signal transduction or regulatory processes.
Its recombinant form serves as a critical tool for antibody development, structural studies (X-ray crystallography or cryo-EM), and in vitro interaction assays. However, the lack of phenotypic data from knockout models or disease associations limits definitive functional claims. Further proteomic and transcriptomic analyses are required to clarify its physiological context and potential relevance to human health.
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