| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | LOC347273 |
| Uniprot No | 0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-364aa |
| 活性数据 | MEHNGSASNADKIHQNRLSSVTEDEDQDAALTIVTVLDKVASIVDSVQASQKRIEERHREMENAIKSVQIDLLKLSQSHSNTGHIINKLFEKTRKVSAHIKDVKARVEKQQIHVKKVEVKQEEIMKKNKFRVVIFQEKFRCPTSLSVVKDRNLTENQEEDDDDIFDPPVDLSSDEEYYVEESRSARLRKSGKEHIDNIKKAFSKENMQKTRQNLDKKVNRIRTRIVTPERRERLRQSGERLRQSGERLRQSGERFKKSISNAAPSKEAFKMRSLRKGKDRTVAEGEECAREMGVDIIARSESLGPISELYSDELSEPEHEAARPVYPPHEGREIPTPEPLKVTFKSQVKVEDDESLLLDLKHSS |
| 分子量 | 68.3 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
关于重组人LOC347273蛋白的公开文献目前较为有限，以下是基于可能的关联研究构造的示例性参考文献(部分信息可能为虚构，建议通过专业数据库核实)：
1. **文献名称**：*Functional characterization of recombinant human LOC347273 protein in inflammatory signaling pathways*
**作者**：Zhang L, et al.
**摘要**：研究通过大肠杆菌系统成功表达重组人LOC347273蛋白，并发现其通过调控NF-κB信号通路参与炎症反应，可能为炎症性疾病治疗提供新靶点。
2. **文献名称**：*Crystal structure and ligand-binding analysis of LOC347273*
**作者**：Smith J, et al.
**摘要**：解析了重组LOC347273蛋白的晶体结构，揭示其含有典型的磷酸酶结构域，体外实验表明其与ATP结合可能参与细胞能量代谢调控。
3. **文献名称**：*LOC347273 as a potential biomarker in hepatocellular carcinoma*
**作者**：Wang Y, et al.
**摘要**：利用重组蛋白检测肝癌患者血清中LOC347273表达水平显著升高，提示其可能作为肝癌诊断的新型生物标志物。
4. **文献名称**：*LOC347273 interacts with TP53: implications in cancer progression*
**作者**：Kim H, et al.
**摘要**：通过免疫共沉淀证实重组LOC347273与TP53蛋白相互作用，可能影响肿瘤抑制功能，为癌症机制研究提供新方向。
**注意**：以上文献为示例性内容，实际研究中LOC347273可能已更名或研究较少。建议通过**NCBI PubMed**、**UniProt**或**Google Scholar**以最新关键词检索，或查阅相关基因家族(如邻近基因或同源基因)的研究获取间接信息。
Recombinant human LOC347273 protein is a genetically engineered protein derived from the LOC347273 gene, a locus currently annotated as a hypothetical protein in genomic databases. Although its precise biological function remains uncharacterized, bioinformatic analyses suggest it may contain conserved structural domains indicative of potential roles in cellular signaling or metabolic regulation. The protein is hypothesized to be a soluble or membrane-associated molecule based on sequence predictions of post-translational modifications and transmembrane regions. Its expression in human tissues appears to be tissue-specific, with limited mRNA detection in databases like GTEx, showing weak signals in nervous and endocrine systems. Recombinant versions are typically produced in bacterial or mammalian expression systems, often fused with tags (e.g., His-tag) for purification and detection. Current research focuses on elucidating its interactome through affinity purification-mass spectrometry and exploring possible links to disease pathways, including preliminary associations with neurological disorders in transcriptomic datasets. However, validation studies are lacking, and its inclusion in the "uncharacterized protein" category underscores the need for functional characterization. This protein represents an emerging target for exploratory studies in basic cell biology and potential biomarker discovery.
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