| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | LOC283874 |
| Uniprot No | 0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-482aa |
| 活性数据 | MWTVPSFTNDSYQVYNVFSTNSFQLLTVKRTPHEAWRVPLTTKTNKTKGLPDCPKKPTNGPFIVTSILWDNCNAPKAVVLQTLAMGIVIDWAPKGHYWQDCSSKNTLCSEFIYSLDYIEHGWQSYTMRQRVSPYPFKWMDTGIAPPRPKIIHPFFTPEHPELWKLAAALSGIKIWNTTYQLLRTKTKTPTFNITLISEWVIPIRSCVKPPYMLLVGNIIMMPDAQTIECHNCKLFTCIDATFNPTTSILLVRAREGVWIPVSLHRPWESSPSIHIVNEVLKDILKRTKRFIFTLIAVLAGLLAVTATAATAGVAIRSSVQTAHYVEACQKNSSRLWNSQAQIDQKLANQINDLRQSVTWLGDRVMNLQHRMQLQCDWNTSDYCITPYAYNQDQHSWENVSRHLKAWDDNLTLDISQLKEQIFEASQAHLSTVPGSHIFEGITKQLPDFNPFKWLKPVRGSLLLLALLILVCLCCLLLVCRCL |
| 分子量 | 81.4 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是根据现有知识整理的关于重组人LOC283874蛋白的假设性参考文献示例(注：实际文献可能需要进一步验证，以下为模拟内容)：
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1. **文献名称**: "Cloning and Functional Characterization of Recombinant Human LOC283874 Protein"
**作者**: Zhang et al.
**摘要**: 本研究成功克隆了人LOC283874基因，并在大肠杆菌表达系统中纯化出重组蛋白。功能实验表明该蛋白可能通过调控MAPK信号通路参与细胞增殖抑制。
2. **文献名称**: "LOC283874 Interacts with Neuronal Proteins: Implications for Brain Development"
**作者**: Lee & Kim
**摘要**: 通过重组LOC283874蛋白的体外结合实验，发现其与突触蛋白Synaptophysin存在相互作用，提示其在神经发育中的潜在作用。
3. **文献名称**: "Structural Insights into LOC283874: A Putative Tumor Suppressor"
**作者**: Smith et al.
**摘要**: 利用重组蛋白的晶体结构解析，揭示了LOC283874的SH3样结构域，并通过体外实验证实其抑制乳腺癌细胞迁移的能力。
4. **文献名称**: "Proteomic Analysis of LOC283874 in Human Serum"
**作者**: Wang et al.
**摘要**: 制备高纯度重组LOC283874蛋白用于抗体开发，发现其在结直肠癌患者血清中显著下调，可能作为新型生物标志物。
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**注意**：以上文献信息为示例性质，实际研究可能有限。建议通过PubMed、Google Scholar等平台以关键词“recombinant LOC283874”或“BSDC1”(可能的基因别名)进行最新文献检索。若研究较少，可关注相关蛋白家族或通路的研究。
LOC283874 is a human gene encoding a protein with limited functional characterization, currently annotated under a provisional identifier due to incomplete understanding of its biological role. It is mapped to chromosome 9 (9q31.1) and is predicted to encode a secreted or membrane-associated protein based on sequence analysis, featuring conserved domains implicated in protein-protein interactions or enzymatic activity. Tissue expression profiles suggest variable mRNA levels in organs like the brain, kidney, and testis, though its physiological relevance remains unclear.
Recombinant human LOC283874 protein is typically produced via heterologous expression systems (e.g., E. coli, mammalian cells) for functional studies. Research efforts focus on elucidating its potential involvement in cellular processes such as signal transduction, metabolic regulation, or immune modulation. Interest in this protein has grown due to bioinformatic associations with diseases, including cancer and neurological disorders, though experimental validation is lacking. Structural studies aim to resolve its 3D conformation to infer binding partners or catalytic mechanisms. Challenges include low natural abundance and absence of specific antibodies, necessitating recombinant tools for antibody generation and mechanistic assays. Current investigations prioritize defining its interactome, physiological substrates, and therapeutic potential, positioning it as a candidate for exploratory biomarker or drug target research.
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