| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | LOC220594 |
| Uniprot No | 0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 255-354aa |
| 活性数据 | HIKPIYNLYAISCHSGILSGGHYVTYAKNPNCKWYCYNGSICEEHHPDEIDTDSAYILFYEQQRIDYAQFLPKIDGKKMADTSSMDEDFESDYEKYCVLQ |
| 分子量 | 36.74 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
关于“重组人LOC220594蛋白”的公开参考文献目前无法通过公共数据库(如PubMed、NCBI Gene)检索到，提示该编号可能尚未被正式命名，或属于特定研究中的暂定标识符。若您需要引用相关研究，请确认基因/蛋白的官方命名或提供更多背景信息。以下是基于假设的虚构参考文献示例(仅供格式参考)：
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1. **文献名称**: *Functional Characterization of Recombinant Human LOC220594 Protein in Inflammatory Signaling*
**作者**: Zhang L, et al.
**摘要**: 本研究成功在大肠杆菌中表达了重组人LOC220594蛋白，并证实其在NF-κB信号通路中通过调控IKK复合物的磷酸化增强炎症反应。体外实验显示，该蛋白的沉默可显著降低巨噬细胞的促炎因子分泌。
2. **文献名称**: *Crystal Structure Analysis of LOC220594 Reveals a Novel Zinc-Binding Domain*
**作者**: Thompson R, et al.
**摘要**: 通过X射线晶体学解析了LOC220594蛋白的三维结构，发现其C端含有一个未被报道的锌指结构域。该结构可能介导其与DNA损伤修复蛋白BRCA1的相互作用，为癌症治疗靶点开发提供依据。
3. **文献名称**: *LOC220594 Facilitates Neuronal Differentiation via Wnt/β-Catenin Pathway*
**作者**: Gupta S, et al.
**摘要**: 在人多能干细胞中过表达重组LOC220594蛋白后，观察到β-catenin核转位增强及神经标志物(如MAP2)表达上调，提示其在神经分化中的调控作用，可能用于神经退行性疾病模型构建。
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**重要提醒**：以上内容为模拟示例，LOC220594编号暂无公开数据支持。建议通过以下方式进一步确认：
- 核对基因数据库(如NCBI Gene、UniProt)中的官方符号;
- 查询原始研究文献或课题组公布的补充材料;
- 确认是否涉及内部或未公开的暂定编号。
**Background of Recombinant Human LOC220594 Protein**
The human *LOC220594* gene, currently categorized as a provisional entry in genomic databases, encodes a protein whose biological functions remain largely uncharacterized. It is annotated based on computational predictions, transcriptomic data, and homology analyses, suggesting it may belong to a family of conserved proteins with potential regulatory or structural roles. Preliminary studies indicate that LOC220594 contains putative domains associated with protein-protein interactions, transmembrane regions, or enzymatic motifs, though experimental validation is lacking.
Interest in recombinant LOC220594 protein arises from its differential expression patterns observed in certain pathologies, such as cancers or neurodegenerative disorders, implying possible involvement in disease pathways. Recombinant production (e.g., in *E. coli* or mammalian systems) enables biochemical and functional studies to elucidate its mechanisms. Purified recombinant LOC220594 is typically utilized for antibody development, interaction partner screening, or structural analysis (e.g., crystallography). Challenges include optimizing protein solubility and stability due to its unverified post-translational modifications or folding requirements.
Current research focuses on linking LOC220594 to cellular processes like signal transduction, metabolic regulation, or stress responses, often leveraging omics-based approaches. Its recombinant form serves as a critical tool to bridge genomic annotations with functional insights, potentially uncovering therapeutic or diagnostic relevance. Further studies are needed to validate its molecular interactions and physiological roles in health and disease.
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