| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | LCE1C |
| Uniprot No | Q5T751 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-118aa |
| 活性数据 | MSCQQSQQQCQPPPKCTPKCPPKCPTPKCPPKCPPKCPPVSSCCSVSSGGCCGSSSGGSCGSSSGGCCSSGGGGCCLSHHRRRRSHCHRPQSSGCCSQPSGGSSCCGGGSGQHSGGCC |
| 分子量 | 39.93 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人LCE1C蛋白的3篇参考文献的示例(注：部分信息可能基于领域知识推断，若需真实文献请查询专业数据库)：
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1. **文献名称**：*Expression and Functional Analysis of Recombinant Human LCE1C Protein in Epidermal Differentiation*
**作者**：Smith A, et al.
**摘要**：本研究成功在大肠杆菌中表达了重组人LCE1C蛋白，并验证其在角质形成细胞分化中的作用，发现其可能通过调控脂质代谢影响皮肤屏障功能。
2. **文献名称**：*LCE1C Gene Variants and Recombinant Protein Characterization in Psoriasis Pathogenesis*
**作者**：Zhang L, et al.
**摘要**：通过分析银屑病患者LCE1C基因多态性，结合重组蛋白体外实验，揭示了LCE1C在炎症反应和表皮过度增殖中的潜在调控机制。
3. **文献名称**：*Structural Insights into Recombinant LCE1C Protein by Circular Dichroism and Molecular Docking*
**作者**：Gomez R, et al.
**摘要**：利用圆二色光谱和分子对接技术解析了重组LCE1C蛋白的二级结构，发现其具有典型的β-折叠构象，可能与细胞外基质蛋白互作参与皮肤修复。
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**说明**：以上文献为领域典型研究方向示例，实际文献需通过PubMed或Web of Science检索关键词“recombinant LCE1C”或“LCE1C protein”获取。建议结合具体研究背景筛选近年高影响力论文。
Recombinant human LCE1C (Late Cornified Envelope 1C) protein is a genetically engineered variant of the naturally occurring LCE1C protein, which belongs to the Late Cornified Envelope (LCE) gene family. This family comprises proteins involved in epidermal differentiation and skin barrier formation. LCE1C is specifically expressed in differentiated keratinocytes and plays a role in maintaining skin integrity, particularly under stress conditions like inflammation or mechanical damage. It is part of the epidermal differentiation complex (EDC) on chromosome 1q21. a region linked to psoriasis susceptibility.
Recombinant LCE1C is typically produced using expression systems such as *E. coli* or mammalian cells, enabling controlled production for functional studies. Structurally, it shares features with other LCE proteins, including a high cysteine content and conserved motifs that facilitate protein cross-linking during cornified envelope assembly. Its exact biochemical mechanisms remain partially unclear, though studies suggest potential roles in modulating immune responses, lipid organization, and keratinocyte cohesion.
Research on recombinant LCE1C focuses on its implications in skin disorders like psoriasis, atopic dermatitis, and skin barrier dysfunction. Variations in *LCE1C* gene expression or mutations have been associated with disease susceptibility, making this protein a target for therapeutic or diagnostic exploration. However, functional redundancies within the LCE family and conflicting study outcomes highlight the need for further investigation into its specific contributions to epidermal biology and pathology.
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