| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | KRTAP6-3 |
| Uniprot No | Q3LI67 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-110aa |
| 活性数据 | MTSTTNTMCGSYYRNYNGGHGYGCCGYGGLGCGYGGCGYGCCGYGGLGFGYGGLDCGYGGLGCGYGSFCGCGYRGLDCGYGCGYGYVSHSFCGCGYRCGSGYGSSFGYYY |
| 分子量 | 12.1 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
关于重组人KRTAP6-3蛋白的公开研究文献较少，以下是根据角蛋白关联蛋白(KRTAP)家族相关研究的示例性整理(注：以下文献为假设性示例，建议通过学术数据库进一步验证)：
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1. **文献名称**: *Expression and Characterization of Recombinant Human KRTAP6-3 in Mammalian Cells*
**作者**: Li, X. et al.
**摘要**: 本研究成功在HEK293细胞中表达了重组人KRTAP6-3蛋白，并验证其通过二硫键形成稳定结构，可能与毛发纤维的机械强度调控相关。
2. **文献名称**: *Functional Analysis of KRTAP6-3 in Hair Follicle Development*
**作者**: Wang, Q. & Smith, J.
**摘要**: 通过CRISPR技术敲减小鼠同源基因发现，KRTAP6-3缺失导致毛发直径减小，提示其在角蛋白交联中起关键作用。重组蛋白体外实验证实其与KRT82的结合能力。
3. **文献名称**: *Genetic Variations of KRTAP6-3 and Their Association with Alopecia*
**作者**: Gomez, R. et al.
**摘要**: 通过对脱发患者基因测序发现，KRTAP6-3的特定突变影响重组蛋白的稳定性，可能导致毛囊结构异常，为遗传性脱发机制提供新见解。
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**建议**：
- 实际文献可通过PubMed或Google Scholar检索关键词如 **"KRTAP6-3 recombinant"** 或 **"KRTAP6-3 keratin associated protein"**。
- 可拓展研究到KRTAP家族其他成员(如KRTAP6-1/6-2)的表达及功能文献。
Recombinant human KRTAP6-3 protein is a synthesized form of the human keratin-associated protein 6-3. a member of the keratin-associated protein (KAP) family. KAPs are critical components of hair and wool fibers, interacting with keratin intermediate filaments to form the structural matrix of these tissues. KRTAP6-3. encoded by the *KRTAP6-3* gene on chromosome 21q22.1. belongs to the high sulfur-containing KAP group, characterized by cysteine-rich sequences that contribute to disulfide bond formation and structural stability. This protein is expressed in hair follicle cells, influencing hair texture, strength, and elasticity. Its genetic variations have been linked to differences in human hair characteristics. Recombinant KRTAP6-3 is produced via heterologous expression systems (e.g., *E. coli* or mammalian cells) to study its biochemical properties, interactions with keratins, and potential applications in biomaterial development or hair disorder research. Current studies focus on its role in hair morphogenesis, its response to environmental stressors, and its molecular interactions within the hair shaft cuticle. Challenges in recombinant production include maintaining proper post-translational modifications (e.g., sulfhydryl crosslinking) essential for its native functionality. Research on KRTAP6-3 may advance cosmetic science, tissue engineering, and therapeutic strategies for hair-related pathologies.
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